JollyRoger
Senior Member
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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.123.323017
Cardiac Vagal Nerve Activity Increases During Exercise to Enhance Coronary Blood Flow
Julia Shanks, Mridula Pachen, Joshua W.-H. Chang, Bindu George and Rohit Ramchandra
Originally published 29 Aug 2023https://doi.org/10.1161/CIRCRESAHA.123.323017Circulation Research. 2023;0
Chronic direct recordings of cardiac vagal nerve activity, cardiac output, coronary artery blood flow, and heart rate were recorded in conscious adult sheep during whole-body treadmill exercise. Cardiac innervation of the left cardiac vagal branch was confirmed with lipophilic tracer dyes (DiO). Sheep were exercised with pharmacological blockers of acetylcholine
Left cardiac vagal branch denervation attenuated the maximum changes in coronary artery blood flow (maximum exercise, control: 63.5±5.9 mL/min, n=8; cardiac vagal denervated: 32.7±5.6 mL/min, n=6, P=2.5×10−7), cardiac output, and heart rate during exercise.
Conclusions:
Our study demonstrates that cardiac vagal nerve activity actually increases and is crucial for maintaining cardiac function during exercise. Furthermore, our findings show the dynamic modulation of coronary artery blood flow during exercise is mediated by VIP.
This study has nothing to do with Me/CFS.
But it shows the importance of the vagus nerve during exercise.
The denervation of the vagus nerve in sheep changes cardiac output etc.
Cardiac Vagal Nerve Activity Increases During Exercise to Enhance Coronary Blood Flow
Julia Shanks, Mridula Pachen, Joshua W.-H. Chang, Bindu George and Rohit Ramchandra
Originally published 29 Aug 2023https://doi.org/10.1161/CIRCRESAHA.123.323017Circulation Research. 2023;0
Chronic direct recordings of cardiac vagal nerve activity, cardiac output, coronary artery blood flow, and heart rate were recorded in conscious adult sheep during whole-body treadmill exercise. Cardiac innervation of the left cardiac vagal branch was confirmed with lipophilic tracer dyes (DiO). Sheep were exercised with pharmacological blockers of acetylcholine
Left cardiac vagal branch denervation attenuated the maximum changes in coronary artery blood flow (maximum exercise, control: 63.5±5.9 mL/min, n=8; cardiac vagal denervated: 32.7±5.6 mL/min, n=6, P=2.5×10−7), cardiac output, and heart rate during exercise.
Conclusions:
Our study demonstrates that cardiac vagal nerve activity actually increases and is crucial for maintaining cardiac function during exercise. Furthermore, our findings show the dynamic modulation of coronary artery blood flow during exercise is mediated by VIP.
This study has nothing to do with Me/CFS.
But it shows the importance of the vagus nerve during exercise.
The denervation of the vagus nerve in sheep changes cardiac output etc.