Is it just me, or does all this talk about ME/CFS being "autoimmune" making anyone else nervous? How does autoimmunity explain clusters and transmission? I appreciate the fact that they are getting a lot of funding and useful info out of studies following the rather serendipitous discovery that Rituximab effects the symptoms of ME. But just because Rituximab helps the symptoms of some people with ME, doesn't mean that ME is autoimmune by nature. Likewise, just because scientists can observe that the immune system is active in ME patients and they have yet to find a pathogen to explain this doesn't mean its by default "autoimmune". Just think, if that were the case, researchers would have declared pretty much much every infectious disease ever discovered in history "autoimmunity" on account of their ability to detect an immune response in patients before they even started looking for the root pathogen causing the response. Come on guys, don't give up and call it the immune response "autoimmune" - you haven't even really started looking for the cause yet.