Thiamine-reduced fatigue in quiescent inflammatory bowel disease is linked to Faecalibacterium prausnitzii; Bermudez-Sanchez; August 2024

[Mary]

This is a Journal Pre-Proof: https://www.ghadvances.org/article/S2772-5723(24)00127-4/pdf

https://www.msn.com/en-us/health/ot...S&cvid=0bcf3d6187d1418396ecdd12cefb9fc5&ei=91

Maybe this would be a clue as to why some of us (including me) respond to thiamine supplementation with increased energy, and some don't. I don't have IBD btw. Anyways, my response to taking 100 mg. of thiamine several years ago was almost immediate - within a day - with a really nice surge of energy I had not had for a very long time. Followed rapidly by severe fatigue (apparently refeeding syndrome) which tanked my phosphorous and I had to start taking a phosphorous supplement, which I still have to take. But I get to keep taking my B-1.

Faecalibacterium prausnitzii is one of the most abundant bacterial species in the gut:

https://www.nature.com/articles/ismej2016176

 

[LINE]

Good post, one of the better articles on this bacteria. F. prausnitzii is a butyrate producer (and there are others). They have found low levels of it in ME studies.

This bacteria and the other butyrate producers are reduced when dealing with other microbes (bad ones) in the gut. IBS is a good sign that there are unwanted bugs in the gut.

 

[LINE]

If I may add. Since prausnitzii produces butyrate, the butyrate reduces inflammatory cytokines such as NF kB.

Excessive NF kB creates many problems such as reducing mitochondria production, with low mitochondria production, the cells lose their robustness. It also attacks the intestinal tract which causes permeability which leads to more inflammation.

They discuss various nutrients that aid in the production including many b vitamins as Mary suggests, they also mention some prebiotics such as pectin (apples etc.). They also mention N-acetylglucosamine which is also known as NAG. Inulin is also discussed; this is found in various plants such as asparagus.

My experience is the best options is simply trial and error, some things have been proposed to work but did not.

 

[Mary]

They also mention N-acetylglucosamine which is also known as NAG.

Interesting - I've been taking NAG at night to help with sleep for many months now. It's one of the supplements @Hip credits with reducing his severe anxiety so I figured it might help with sleep and I think it helps a little.

My experience is the best options is simply trial and error,

I completely agree!

 

[LINE]

@Mary Don't forget that glycine is involved in the gut environment, and it helps the barrier integrity. A better gut barrier integrity means less anxiety. I followed your advice on the glycine and it did work!

 

[skinnybane]

https://www.news-medical.net/news/2...role-in-reducing-fatigue-in-IBD-patients.aspx

"However, RCT patients who reported relief of fatigue after taking thiamine exhibited more abundant Fecalibacterium prausnitzii and Roseburia hominis in pre- and post-treatment samples as compared with those who did not respond to the treatment. The relative abundances of these microorganisms in pre- and post-treatment samples was negatively associated with the IBD fatigue score in patients with chronic fatigue.

Fecalibacterium prausnitzii and Roseburia hominis may be useful biomarkers to identify patients with quiescent IBD and chronic fatigue who will respond to high-dose thiamine supplementation."

TLDR it is possible that thiamine works by increasing SCFA producing bacteria.

Some other random stuff I found on it:

“Acetaldehyde induces a deficiency of vitamin B1. Thiamin, or Vitamin B1, is so critical to brain and nerve function it is often called the "nerve vitamin." AH has a very strong tendency to combine with B1, as the work of Herbert Sprince, M.D. (discussed below) has shown. (7)"

Things like candida produce acetaldehyde.

"Ruminococcaceae Genomes Lack the Vitamin B1 Synthesis Pathway"

"Ruminococcaceae Abundance Is Correlated with Vitamin B1 Intake in Humans"

"B1-deficient group showed a decreased relative abundance of Ruminococcaceae, Lachnospiraceae, Rhodospirillaceae, and Alcaligenaceae, as well as an increased relative abundance of Bacteroidaceae, Verrucomicrobiaceae, Christensenellaceae, and Clostridiaceae."

"vitamin B1 is involved in butyrate synthesis as a cofactor"

"fecal butyrate levels were significantly decreased under vitamin B1-deficient conditions"

 

[LINE]

@skinnybane B1 as benfotiamine is in my rotation and seems to help. I have many things in the rotation which makes things a little difficult to isolate but I would say that benfotiamine is helpful.

Fecalibacterium prausnitzii and Roseburia hominis may be useful biomarkers to identify patients with quiescent IBD and chronic fatigue who will respond to high-dose thiamine supplementation."

Good find! Those 2 (f. prausnitzii and Roseburia) were studied in CFS patients and found to be low. It is all starting to make sense now.