Young female rat pups received daily aceclofenac (5, 10, and 20 mg/kg, i.p., n = 10) between postnatal day 56 and 76.
The effects of aceclofenac were compared with assessment of behavioral tests and
ELISA results. D
uring the postnatal days (PNDs) 73–76, behavioral tests were conducted in rats, and on PND 76,
ELISA tests were performed to examine the changes in
Tumor necrosis factor alpha (TNF-α), Interleukin-1β (IL-1β), Brain-derived neurotrophic factor (BDNF), and
nestin levels.
Aceclofenac treatment reversed deficits in
prepulse inhibition, novel object recognition,
social interaction, and locomotor activity tests.
In addition, aceclofenac administration decreased TNF-α and IL-1β expression in the prefrontal cortex and hippocampus.
