percyval577
nucleus caudatus et al
- Messages
- 1,320
- Location
- Ik waak up
I found the following idea only in this article:
Reorganizing metals: the use of chelating compounds as potenial therapies for metal-related neurodegeneraive disease
Badrick and Jones 2011
abtract
The idea easily applies also to non-neurodegenerative diseases, if I am no too supid.
Especially promising would be a disease that had been triggered, but only/mainly had been disturbed in metal-distribution.
Metals may be thought of as roads with actions taking place along them.
ME/CFS could be a candidate here.
Reorganizing metals: the use of chelating compounds as potenial therapies for metal-related neurodegeneraive disease
Badrick and Jones 2011
abtract
Metal ions, particularly copper, zinc and iron, are implicated in several amyloidogenic neurodegenerative disorders. In the brain, as elsewhere in the body, metal ion excess or deficiency can potentially inhibit protein function, interfere with correct protein folding or, in the case of iron or copper, promote oxidative stress.
The involvement of metal ions in neurodegenerative disorders has made them an emerging target for therapeutic interventions. One approach has been to chelate and sequester the ions and thus limit their potential to interfere with protein folding or render them unable to undergo redox processes.
Newer approaches suggest that redistributing metal ions has therapeutic benefits, and recent studies indicate that alleviating cellular copper deficiency may be a plausible way to limit neurodegeneration. In this review we discuss the role of metals in amyloidogenic, neurodegenerative disorders and highlight some mechanisms and compounds used in various therapeutic approaches.
paywalled
Curr Top Med Chem. 2011;11(5):543-52.
Curr Top Med Chem. 2011;11(5):543-52.
The idea easily applies also to non-neurodegenerative diseases, if I am no too supid.
Especially promising would be a disease that had been triggered, but only/mainly had been disturbed in metal-distribution.
Metals may be thought of as roads with actions taking place along them.
ME/CFS could be a candidate here.