- Messages
- 171
- Location
- London
Has anyone had any improvements in myalgia from enhancing pyruvate dehydrogenase activity through the high dose supplementation of specific co-factors:
Benfotiamine 500mgs every 8 hours
Alpha Lipoic Acid 600mgs every 8hrs
Acetyl Carnitine (+) fatty acid oxidation, 1500mgs every 8 hours.
(also 100mg Riboflavin for FAD and NADH 10mg/D)
None of the above seem to have any noticeable benefit in isolation, so will determine if any synergistic effect. I have had success in ameliorating severe myalgia using an optimized form of Curcumin, where everything else tried (including ubiquinol, methylation targeted supplements and analgesics) had no marked effect but the cost of curcumin is high.
http://www.ncbi.nlm.nih.gov/pubmed/3405240
http://www.ncbi.nlm.nih.gov/pubmed/8596197
http://www.ncbi.nlm.nih.gov/pubmed/12379317
Benfotiamine 500mgs every 8 hours
Alpha Lipoic Acid 600mgs every 8hrs
Acetyl Carnitine (+) fatty acid oxidation, 1500mgs every 8 hours.
(also 100mg Riboflavin for FAD and NADH 10mg/D)
None of the above seem to have any noticeable benefit in isolation, so will determine if any synergistic effect. I have had success in ameliorating severe myalgia using an optimized form of Curcumin, where everything else tried (including ubiquinol, methylation targeted supplements and analgesics) had no marked effect but the cost of curcumin is high.
http://www.ncbi.nlm.nih.gov/pubmed/3405240
http://www.ncbi.nlm.nih.gov/pubmed/8596197
http://www.ncbi.nlm.nih.gov/pubmed/12379317
