Study reveals that severe exercise-induced Myopathy, tissue infiltration with amyloid-containing deposits and metabolic disturbances in Skeletel mscls

[JasonPerth]

https://x.com/resiapretorius/status/1696272269641764949?s=46&t=MKOhMke7DuglGcTS-Q6VQw

Link above:

Can anyone smarter then me provide more info.
Is this excactly what was expected as its excactly what we experience and feel with PEM and exercise with muscles just not working properly.

Is MECFS myopathy? Or a form of its own Myopathy?

Im confused

 

[junkcrap50]

I think this is just another piece to the puzzle. I'm not sure if any other diseases, particularly neuromuscular diseases, also have amyloid deposits in the muscle tissue (I haven't searched for it), but I would assume no. The metabolic disturbances are consistent with previous me/cfs research.

It appears that these amyloid-containing deposits are the very same microclots that have been found in Long COVID & some ME/CFS patients' blood.

 

[Wishful]

If it is found in some PWME, I expect it's a downstream effect of ME in some subgroups, rather than a core part. The only muscle symptom my ME has is neurological aches which were blocked by LDN, which doesn't fit with a theory of deposits or microclots.

 

[Oliver3]

This seems like a phenotype reaction . It's so body wide how can it be just a virus or whatever that's causing this.
It's gotta be genetic but why do they never find strong genetic kinks.
In my opinion , you can see a potential sufferer of m.e. before they get it Ill. The pallor, the muscle distribution, gait etc...it's all there

 

[Wishful]

In my opinion , you can see a potential sufferer of m.e. before they get it Ill. The pallor, the muscle distribution, gait etc...it's all there

No, I didn't show any signs before my ME. I was healthy and active.

I don't think it's genetic, or rather that it could be a combination of various genes and epigenetic changes that sets the stage for some pathway to snap into an abnormal state.

As for body wide, that's the symptoms, not the core dysfunction. The core dysfunction could be one single pathway in just a few cells in one part of the brain, but the cascade effects could be body-wide. My ME doesn't involve muscle problems or ATP production problems or digestive problems; all the symptoms seem to be neurological in origin.

 

[JasonPerth]

No, I didn't show any signs before my ME. I was healthy and active.

I don't think it's genetic, or rather that it could be a combination of various genes and epigenetic changes that sets the stage for some pathway to snap into an abnormal state.

As for body wide, that's the symptoms, not the core dysfunction. The core dysfunction could be one single pathway in just a few cells in one part of the brain, but the cascade effects could be body-wide. My ME doesn't involve muscle problems or ATP production problems or digestive problems; all the symptoms seem to be neurological in origin.

Agreed. Nobody can see it coming. Same with many other random things like cancer and MND. I was 18 and playing sport every second day. One Cough virus later- and ive never been the same since and 7 years later bedbound.

Im unsure on the physical exame an Osteopath that practices the perrin technique. Apparently they can feel physcial parts like the “perrin point” on us including healthy people that are susceptible.
Also the HLA Gene that 24% of the population has.
Apparently 100% of C.I.R.S patients have the gene to get a diagnosis. And many believe MECFS is C.I.R.S
But this is debatable depending who says what