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Study: Annual Vaccination against Influenza Virus Hampers Development of Virus-Specific CD8+ T Cell Immunity in Children

X

xcell

Always looking for new knowledge and options!
Messages
94
Location
Germany
A study shows that the immune system after influenza vaccine is weaker against other viruses than without influenza vaccination.

J Virol. 2011 Nov; 85(22): 11995–12000.
doi: 10.1128/JVI.05213-11
PMCID: PMC3209321
PMID: 21880755
Annual Vaccination against Influenza Virus Hampers Development of Virus-Specific CD8+ T Cell Immunity in Children▿
Rogier Bodewes,1 Pieter L. A. Fraaij,1,2 Martina M. Geelhoed-Mieras,1 Carel A. van Baalen,3 Harm A. W. M. Tiddens,4 Annemarie M. C. van Rossum,5 Fiona R. van der Klis,6 Ron A. M. Fouchier,1 Albert D. M. E. Osterhaus,1,3 and Guus F. Rimmelzwaan1,3,*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209321/

Abstract
Infection with seasonal influenza A viruses induces immunity to potentially pandemic influenza A viruses of other subtypes (heterosubtypic immunity). We recently demonstrated that vaccination against seasonal influenza prevented the induction of heterosubtypic immunity against influenza A/H5N1 virus induced by infection with seasonal influenza in animal models, which correlated with the absence of virus-specific CD8+ T cell responses. Annual vaccination of all healthy children against influenza has been recommended, but the impact of vaccination on the development of the virus-specific CD8+ T cell immunity in children is currently unknown. Here we compared the virus-specific CD8+ T cell immunity in children vaccinated annually with that in unvaccinated children. In the present study, we compared influenza A virus-specific cellular and humoral responses of unvaccinated healthy control children with those of children with cystic fibrosis (CF) who were vaccinated annually. Similar virus-specific CD4+ T cell and antibody responses were observed, while an age-dependent increase of the virus-specific CD8+ T cell response that was absent in vaccinated CF children was observed in unvaccinated healthy control children. Our results indicate that annual influenza vaccination is effective against seasonal influenza but hampers the development of virus-specific CD8+ T cell responses. The consequences of these findings are discussed in the light of the development of protective immunity to seasonal and future pandemic influenza viruses.
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X

xcell

Always looking for new knowledge and options!
Messages
94
Location
Germany
Can this study result also be transferred to other vaccinations?
So these also worsen the immunity against other viruses?
 
G

geraldt52

Senior Member
Messages
602
xcell said:
Can this study result also be transferred to other vaccinations?
So these also worsen the immunity against other viruses?
Click to expand...
It's hard to imagine that it wouldn't apply to all vaccines, isn't it?

Vaccines have become such a sacred cow that even talking about negative side effects, let alone seriously investigating them, would seem to be a sure career-killer. I'm not astonished at the results of this study, but I am astonished that it was published.
 
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