[Study] Airway-delivered short-chain fatty acid acetate boosts antiviral immunity during rhinovirus infection Oct 2022

[godlovesatrier]

https://www.jacionline.org/article/S0091-6749(22)01331-8/fulltext

Interesting because it proves that if these scfas are low then you'd have a worsened general antiviral response. As all the main scfas Inc butyrate modulated interferon and cytokines in such a way as to calm the immune system whilst also stimulating it's natural antiviral capability.

 

[godlovesatrier]

And another similair study but in infants

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871125/

Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis

 

[godlovesatrier]

Maybe unsurprisingly they don't appear to have any direct effect on sars cov-2 infection in the intestines:

Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples

https://www.tandfonline.com/doi/full/10.1080/19490976.2021.1874740