Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hp axis

[clive powney]

http://www.ncbi.nlm.nih.gov/pubmed/22771318

 

[wdb]

CFS was induced by forcing the rats to swim for 15mins for 21 consecutive days.

I think they are confusing general fatigue with CFS

 

[adreno]

Interesting, but I would like to know how shilajit works long term. Things that stimulate the HPA axis have a habit of only working for a short period of time, before the HPAA adapts.

 

[Bob]

I think they are confusing general fatigue with CFS

Yes, it looks like the rats just have general fatigue. They are physically stressed. Physically exhausted at worst.

And I don't really see how it's possible diagnose a rat with CFS anyway, because you can't ask them about muscle and joint pain, headaches, unrefreshing sleep or sore throats etc.

I've never heard 'shilajit' before, so I looked it up on wikipedia: http://en.wikipedia.org/wiki/Shilajit
It seems like a bizarre substance... It's a naturally occuring mineral substance that "seeps from cracks in mountains"!
It looks like there have been quite a number of research papers on it.

 

[biophile]

Chronic exercise is a fairly common "trigger" in CFS animal studies. At best it mimics overtraining syndrome which may have vague similarities, but I wouldn't put much stock in such studies for CFS. Other methods I've read about include introducing a pathogen or toxin. ScienceDaily.com recently posted an article about a new development in understanding the biology of depression, which also discusses the inadequacies of behavioural measurements in lab animals (http://www.sciencedaily.com/releases/2012/07/120711134714.htm).

 

[wdb]

Chronic exercise is a fairly common "trigger" in CFS animal studies. At best it mimics overtraining syndrome which may have vague similarities, but I wouldn't put much stock in such studies for CFS. Other methods I've read about include introducing a pathogen or toxin. ScienceDaily.com recently posted an article about a new development in understanding the biology of depression, which also discusses the inadequacies of behavioural measurements in lab animals (http://www.sciencedaily.com/releases/2012/07/120711134714.htm).

Yes overtraining syndrome would be a much better description. Whatever those rats had it wasn't chronic, they would have recovered by resting regardless of treatment.

Still at least no weasels were involved

 

[Tito]

Still at least no weasels were involved

it would be against the law to give rats CBT. They are rats and they deserve respect. ;-)

 

[Sherlock]

shilajit IIRC can be a source of lithium

 

[Desdinova]

That's not CFS nor is it ME that's CF via Over-training. The people who keep doing these garbage studies are either biased, ignorant and need a Super Giant Billboard Spelling out exactly what CFS is and isn't or both.