- Messages
- 45
- Location
- Netherlands
Sepsis is mentioned recently in me/cfs research and by researchers.
They say inflammation in me/cfs looks like sepsis. Only difference is that in me/cfs it looks more like slow chronic low grade sepsis instead of acute sepsis.
I read this article about injecting mesenchymal stemcells in mice induced sepsis as a way of restoring mitodna and metabolic pathways. Hence lowering cytokines, ros and sepsis.
My questions are
1. are there me/cfs studies that have looked at mitochondrial muscle stem cells?
2. The article mentions of a decrees of Pgc1a as a master regulator of ROS detoxification, gluconeogenesis, mito biogenesis, metabolism and muscle wasting. Is this also the case in me/cfs? Has this been studied maybe genetic defect of Pgc1a?
I have read in one research that in fm patients Pgc1a is lower than me and healthy control
3. Can these stemcell be a key to solving this disease as is the case in the mouse model with sepsis? Just thinking out loud...I know mice are not human beings. But using your own stemcells is not a bad idea..
4. Jose montoya mentioned in one of his recent presentations wanting to look at stem cells..has this some relations?
https://www.nature.com/articles/ncomms10145
Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy
They say inflammation in me/cfs looks like sepsis. Only difference is that in me/cfs it looks more like slow chronic low grade sepsis instead of acute sepsis.
I read this article about injecting mesenchymal stemcells in mice induced sepsis as a way of restoring mitodna and metabolic pathways. Hence lowering cytokines, ros and sepsis.
My questions are
1. are there me/cfs studies that have looked at mitochondrial muscle stem cells?
2. The article mentions of a decrees of Pgc1a as a master regulator of ROS detoxification, gluconeogenesis, mito biogenesis, metabolism and muscle wasting. Is this also the case in me/cfs? Has this been studied maybe genetic defect of Pgc1a?
I have read in one research that in fm patients Pgc1a is lower than me and healthy control
3. Can these stemcell be a key to solving this disease as is the case in the mouse model with sepsis? Just thinking out loud...I know mice are not human beings. But using your own stemcells is not a bad idea..
4. Jose montoya mentioned in one of his recent presentations wanting to look at stem cells..has this some relations?
https://www.nature.com/articles/ncomms10145
Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy