Scientists identify the first genetic marker for Multiple Sclerosis severity, opening the door to preventing long-term disability.

[Annikki]

Since ME/CFS shares similarities between the autoimmune disorder, Multiple Sclerosis, this article is worth reading. Scientists have found a genetic marker that indicates which MS cases degrade into severe impairment quicker than others. Some MS patients can walk and run, but others wind up wheelchair-bound. The genetic marker found delineates these two patient subsets.

"The variant sits between two genes with no prior connection to MS, called DYSF and ZNF638. The first is involved in repairing damaged cells, and the second helps to control viral infections. The variant's proximity to these genes suggests that they may be involved in the disease's progression.
"These genes are normally active within the brain and spinal cord, rather than the immune system," said Adil Harroud, MD, lead author of the study and former postdoctoral researcher in Baranzini's lab. "Our findings suggest that resilience and repair in the nervous system determine the course of MS progression and that we should focus on these parts of human biology for better therapies."

https://www.sciencedaily.com/releases/2023/06/230628130323.htm

 

[GreenEdge]

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