Retrograde Mitochondrial Pathology identified.
- Thread starter bread.
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Okay, I freely admit that the paper looks far too technically dense for me to read through...and make sense of. I lack the biology background to know what is important and what isn't. It looks like a study of part of a rare genetic disorder, so I don't know whether it might apply in some way to ME. It does seem to show that the immune system / mitochondrial links are complex, so it seems reasonable for such a defect to cause the microglial cells to lock into an abnormal state.
I think I'll let the experts ponder the implications, and report on any findings for ME.
I think I'll let the experts ponder the implications, and report on any findings for ME.
Gemini
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@bread thanks for posting. Always nice to read an open access paper esp. important ones!
Believe findings will be of interest to the "subgroup" of ME/CFS patients with a Primary Immunodeficiency. Many belong to the Immune Deficiency Foundation(IDF), posting on their Forum as well as here on PR over the years.
Agree @Wishful, the paper is very technical illustrating immune system/mitochondrial complexity. Discussion of treatment possibilities is interesting.
IDF has an updated PI patient registry and website https://usidnet.org for anyone interested.
Gemini
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Nice to see the U.S. Clinician Coalition's guidelines for "Diagnosing and Treating ME/CFS" published last month list "immunodeficiencies" under comorbid conditions.
https://forums.phoenixrising.me/thr...s-clinician-coalition-omf.77543/#post-2228056
Rarely tested for during a standard physical exam, many patients may not realize they have a PID. And there are only a few specialists in the U.S. Clinical Immunology field to diagnose/treat them.