Taniaaut1, thank you for the link on articifical sweeteners and natural sweetners.
Valentijn, I found the bit on the thread discussing a person who found they didn't tolerate low carb diets:
'this brings me to an interesting observation which dates back several years before the precipitation of the CFS. Back in '03 she and her sister both got interested in the Atkins diet (which started me on it - I've never looked back). However, instead of reacting as most people do, Curly got very distressingly ill and had to come off it sharply after only a few days, the several times she tried it.
So it seems to me that she's had a block on her gluconeogenesis (GNG) cycle whereby the liver creates glucose from protein in the absence of carbs. I think the body normally prefers the protein path. It is known that insulin inhibits GNG, among other things. I've not read anything to date about this occurring in CFS, however. Has anyone else had this? If so, any fixes?
Hasta la proxima vez,
stressman
Hi, stressman.
I think you are correct about the disturbed HPA axis producing insufficient cortisol in ME/CFS, and this impacting the glucose control. The main driver for gluconeogenesis by the liver is normally cortisol. Hypoglycemia is very common in ME/CFS, and I think that is the reason.
It's very tricky to find an appropriate diet in ME/CFS. I think the reason is as follows: Certain organs, tissues and cells have partially blocked mitochondria, primarily because of glutathione depletion from a variety of causes, depending on the particular case. These organs include the skeletal muscles, immune system cells, certain glands, and to some extent the nervous system. Others, especially the vital organs, do not become as depleted in glutathione during this bodywide scarcity, because they have a complete transsulfuration pathway and are thus able to convert methionine to cysteine, which is the rate-limiting amino acid for making glutathione. So they are better able to provide for themselves, with the happy result that life is preserved, though not nearly as pleasant as one would like it to be! These protected organs include the liver, kidneys, pancreas, intestine, lens of the eye, and to some extent, the nervous system.
What makes choosing a diet tricky is that all the organs, tissues and cells are fed by the same digestive system and served by the same circulating blood. The brain primarily uses glucose as its fuel. Because the HPA axis is dysfunctional, the blood glucose level tends to drop, causing the person to go for a sugar fix in response to an alarm from the brain. However, when the glucose level in the blood comes up, it is supplied at a faster rate than can be used by the body as a whole, mainly because the skeletal muscles represent such a large fraction of the body's total cellular mass, and they have partially blocked mitochondria. Thus, the blood glucose level rises too high, the pancreas responds by raising insulin, and the excess glucose is then converted to stored fat by the liver and the adipocytes, causing weight gain and overshoot of the control system, which is now not well matched to the debilitated system it is trying to control. This overshoot drops the blood glucose level too far, causing the person to go for another sugar fix. And so on.
One possibility would be to go for starch rather than sugar. Starch is broken down to sugar by amylase, but it's a relatively slow process, because amylase can attack only at the ends of the starch molecule's polymeric structure. This feature of starch digestion has been used to maintain the blood glucose level overnight during sleep for children who are diabetic.
In the longer term, the solution has to be to correct the glutathione depletion by lifting the linked partial methylation cycle block, which in turn should correct both the mito dysfunction and the HPA axis dysfunction. I might mention that Dr. de Meirleir believes alternatively that the HPA axis dysfunction in ME//CFS is caused by substances produced by bacteria in the gut. I think he has implicated D-lactate or hydrogen sulfide or both as causing problems in the hypothalamus. He may be right about this. I am finding that there are so many interactions between the partial methylation cycle block and the gut issues in ME/CFS that I think they need to be treated pretty much simultaneously, so that one will not continue to drag the other down. I hope this helps. Regards to Curly.
Best regards,
Rich '
Hope that helps, although i confess I don't fully understand it. I think the person is saying that the body can not handle the gluconeogenisis cycle well due to some kind of block. All I know is that a low carb diet, though fantastic for reducing my sugar cravings and losing some weight (which I need to) made me feel very ill, not just the light headedness, but terrible pain and malaise. This was upsetting for me as i would have liked to have stuck to it for a while longer.
Valentijn, I didn't really understand what you meant when you wrote ' but eating carbs near the beginning of the symptoms didn't help at all, so I've been staying with it'. I don't know what you were referring to exactly when you said 'beginning of the symptoms'. Do you mean the start of getting ill with M.E? Thanks