alcasa
Glutamate +ATP pantheist
- Messages
- 22
Hi everyone,
I’m running low on executive function, so I’ll try to be as practical and to the point as possible. I theorise that perhaps a third to half of CFS might stem from issues related to glutamate uptake, the brain's pumps mechanisms, and overall energy metabolism. If these processes start to malfunction particularly in the prefrontal cortex, it could lead to depersonalisation and derealisation.
Derealisation, which I believe to be the more common issue, is marked by a sense of disconnection from one’s surroundings. The world feels dreamlike, unreal, as though you're watching a film. You might feel emotionally detached from others and from the world around you.
One description I’ve come across, which I think captures it well, is that it feels like there’s something between your eyes and reality. It’s as if you're observing everything – people included – through a telescope, and it all seems artificial, like a dream:
While derealisation is the experience of feeling disconnected from your environment, depersonalisation is a disconnection from oneself – body, mind, and thoughts, often accompanied by physical and emotional numbness.
I’ve suffered from chronic derealisation since the onset of my CFS, but I’ve never experienced depersonalisation.
I need to know if I’m alone in this. I’m quite convinced my condition is driven by excessive CNS excitation and an inability to maintain the gradient necessary for sustained excitation, most likely due to a collapse in glutamate uptake, along with the excessive excitation itself. However, I’d like to know if this is common in CFS, or if I’ve just got a particularly unique subtype that can’t be generalised to others, which would be very sad...
I’m running low on executive function, so I’ll try to be as practical and to the point as possible. I theorise that perhaps a third to half of CFS might stem from issues related to glutamate uptake, the brain's pumps mechanisms, and overall energy metabolism. If these processes start to malfunction particularly in the prefrontal cortex, it could lead to depersonalisation and derealisation.
Derealisation, which I believe to be the more common issue, is marked by a sense of disconnection from one’s surroundings. The world feels dreamlike, unreal, as though you're watching a film. You might feel emotionally detached from others and from the world around you.
One description I’ve come across, which I think captures it well, is that it feels like there’s something between your eyes and reality. It’s as if you're observing everything – people included – through a telescope, and it all seems artificial, like a dream:
While derealisation is the experience of feeling disconnected from your environment, depersonalisation is a disconnection from oneself – body, mind, and thoughts, often accompanied by physical and emotional numbness.
I’ve suffered from chronic derealisation since the onset of my CFS, but I’ve never experienced depersonalisation.
I need to know if I’m alone in this. I’m quite convinced my condition is driven by excessive CNS excitation and an inability to maintain the gradient necessary for sustained excitation, most likely due to a collapse in glutamate uptake, along with the excessive excitation itself. However, I’d like to know if this is common in CFS, or if I’ve just got a particularly unique subtype that can’t be generalised to others, which would be very sad...
The vagus nerve probably plays a role in some symptoms in some people, but I doubt that it's the root cause.