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http://www.theage.com.au/national/h...after-australian-breakthrough-20170816-gxxz10
A breakthrough Melbourne-made treatment that is providing a long-term cure for children with a deadly peanut allergy may soon be widely available.
Two out of three children who received experimental peanut-probiotic treatment four years ago, can still freely eat peanuts today.
"These children have been eating peanut freely in their diet without having to follow any particular program of peanut intake in the years after treatment was completed," said lead researcher Professor Mimi Tang.
The clinical trial was conducted at the Murdoch Children's Research Institute in Melbourne.
Professor Tang hopes a product can be on the shelves in the next five years.
"This changes sufferers' lives. They can now eat peanuts. Their lives change completely," she said.
"Our feedback is these kids are now going to parties without worry."
The treatment combines a small amount of peanut flour with a very high dose of the probiotic Lactobacillus rhamnosus.
This bacterium, commonly found in small doses in yoghurt, is a known immune system modulator – it calms the immune system's response to things it would normally react to, reducing the severity of allergic reactions.
Paired together, the probiotic mix encourages the immune system to gradually tolerate larger and larger doses of peanut flour.
"Probiotics are very potent immune-modulating agents to shift the way the immune system responds. This particular probiotic has been shown in other situations to support tolerance-like responses. It creates an environment for the immune system to respond differently," Professor Tang said
A breakthrough Melbourne-made treatment that is providing a long-term cure for children with a deadly peanut allergy may soon be widely available.
Two out of three children who received experimental peanut-probiotic treatment four years ago, can still freely eat peanuts today.
"These children have been eating peanut freely in their diet without having to follow any particular program of peanut intake in the years after treatment was completed," said lead researcher Professor Mimi Tang.
The clinical trial was conducted at the Murdoch Children's Research Institute in Melbourne.
Professor Tang hopes a product can be on the shelves in the next five years.
"This changes sufferers' lives. They can now eat peanuts. Their lives change completely," she said.
"Our feedback is these kids are now going to parties without worry."
The treatment combines a small amount of peanut flour with a very high dose of the probiotic Lactobacillus rhamnosus.
This bacterium, commonly found in small doses in yoghurt, is a known immune system modulator – it calms the immune system's response to things it would normally react to, reducing the severity of allergic reactions.
Paired together, the probiotic mix encourages the immune system to gradually tolerate larger and larger doses of peanut flour.
"Probiotics are very potent immune-modulating agents to shift the way the immune system responds. This particular probiotic has been shown in other situations to support tolerance-like responses. It creates an environment for the immune system to respond differently," Professor Tang said
