P2X7 receptor polymorphism linked to Bipolar Disorder

[S-VV]

@SlamDancin hello! I recognize your from the Ray Peat Forum, right?

 

[SlamDancin]

@S-VV Different username over on RP but I am a huge fan of Haidut. I have an ongoing dialogue with him and we’ve talked ME/CFS pretty extensively. He’s got an interesting take on CFS we can PM about.

 

[Jackb23]

@Jackb23 how's that purinol experiment going? I'm thinking of trying it myself

I’ve been using it with success, but not exactly in the way I initially thought I would be. I use it as an “as needed” medicine. I have found that it’s very helpful for when I feel agitated or “wired but tired.” My agitation is weird, it’s not an angry agitation or a hyperactive agitation, it’s more of a mental pain as if I’m holding onto an electric fence. It is extremely bizarre. Anyways, allopurinol has been extremely helpful for this— a lot better than any neuroleptic. However, I do not take it constantly because every now and then it will make me a bit more tired. All in all, it’s been a good medicine for me to have in my arsenal.

 

[pattismith]

@pattismith Hey just stumbled on this thread and wanted to suggest IP-6/Inositol as both inhibit XO. I also take a product called Cardenosine (that includes 100mg Inosine) that you should google to further attempt to compensate for lack of ATP production.

Yes, I took Inosine + Inositol and did well with it, until I started Testosterone. I'm still with Testosterone now, and don't need Inosine/inositol any longer. (Testo improved my spine mechanic/spine muscle tone)

 

[pattismith]

I make the hypothesis that MBL deficiency may increase P2X7R ATP binding and consequent P2X7 activation and inflammation...

https://www.frontiersin.org/articles/10.3389/fimmu.2018.01295/full