Interesting new study that may be relevant to ME/CFS stress intolerance. In particular, related to overactive fight-flight response, adrenal insufficiency, or weak parasympathetic resonse. This is about osteocalcin.
Apparently adrenaline is not required for an acute stress response, but osteocalcin is a key factor that shuts down the parasympathetic response, allowing the fight-flight resonse to persist unchecked. Osteocalcin comes from the bones.
Could osteocalcin (or a close analog) be a blood factor in ME/CFS, maybe one of the mystery substances researchers are searching for? Anyone have these levels checked (in a parathyroid panel or in a test for osteoperosis perhaps)? Are they ever high in ME/CFS patients?
Somehow this seems important, I'm trying to work through the article now:
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30441-3
Mediation of the Acute Stress Response by the Skeleton
Abstract Highlights
- The ASR stimulates osteocalcin release from bone within minutes
- Glutamate uptake into osteoblasts is required for osteocalcin release during an ASR
- Osteocalcin inhibits the parasympathetic tone during an ASR
- In adrenal insufficiency, increased osteocalcin levels enablean ASR to occur
Authors
Julian Meyer Berger, Parminder Singh,Lori Khrimian, ..., Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty
(Columbia University and others)
Full PDF: https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(19)30441-3
Apparently adrenaline is not required for an acute stress response, but osteocalcin is a key factor that shuts down the parasympathetic response, allowing the fight-flight resonse to persist unchecked. Osteocalcin comes from the bones.
Could osteocalcin (or a close analog) be a blood factor in ME/CFS, maybe one of the mystery substances researchers are searching for? Anyone have these levels checked (in a parathyroid panel or in a test for osteoperosis perhaps)? Are they ever high in ME/CFS patients?
Somehow this seems important, I'm trying to work through the article now:
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30441-3
Mediation of the Acute Stress Response by the Skeleton
Abstract Highlights
- The ASR stimulates osteocalcin release from bone within minutes
- Glutamate uptake into osteoblasts is required for osteocalcin release during an ASR
- Osteocalcin inhibits the parasympathetic tone during an ASR
- In adrenal insufficiency, increased osteocalcin levels enablean ASR to occur
Authors
Julian Meyer Berger, Parminder Singh,Lori Khrimian, ..., Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty
(Columbia University and others)
Full PDF: https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(19)30441-3
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