Need Internet Reseach Help

[Galixie]

I am trying to get to the bottom of some nutritional deficiencies. So far I have been told I have gastritis (inflammation) but nothing else. I can't find anything that links intestinal inflammation without atrophy to nutrient deficiency. Yet my doctor says,

"Inflammation in the digestion system, regardless of cause, leads to absorption issues."

I would like to see something scientific that either confirms or denies this claim.

My concern is that there might be something else going on that is being overlooked in favor of blaming it on the inflammation alone.

My search skills are rudimentary. I could use some help locating articles. Anyone up for a hunt?

 

[Eastman]

I'm not sure if these are what you are looking for but they are what I could find from a quick search on Google scholar:

Micronutrient Antioxidants in Gastric Mucosa and Serum in Patients with Gastritis and Gastric Ulcer: Does Helicobacter pylori Infection Affect the Mucosal Levels?

Review article: is there a link between micronutrient malnutrition and Helicobacter pylori infection?

The impact of intestinal inflammation on the nutritional environment of the gut microbiota

 

[Seven7]

FYI, I was told I had inflammation on my colonoscopy and ended up being colitis, Apparently if they scrape a little and find inflammation is considered like an inflammatory condition (can't remember exactley) But they kept me undiagnosed for 2 years, so you want to make sure they rule out Chrons or any of the inflammatories conditions. They left me 2 years

 

[Galixie]

I'm not sure if these are what you are looking for but they are what I could find from a quick search on Google scholar:

Micronutrient Antioxidants in Gastric Mucosa and Serum in Patients with Gastritis and Gastric Ulcer: Does Helicobacter pylori Infection Affect the Mucosal Levels?

Review article: is there a link between micronutrient malnutrition and Helicobacter pylori infection?

The impact of intestinal inflammation on the nutritional environment of the gut microbiota

Thanks, but it isn't quite what I'm looking for. I tested negative for h. pylori. I basically have no autoimmune or bacterial reason for the inflammation. It's just there.

 

[Galixie]

FYI, I was told I had inflammation on my colonoscopy and ended up being colitis, Apparently if they scrape a little and find inflammation is considered like an inflammatory condition (can't remember exactley) But they kept me undiagnosed for 2 years, so you want to make sure they rule out Chrons or any of the inflammatories conditions. They left me 2 years

That sounds awful. I'm sorry it took so long. I think, in my case, chrons is already ruled out because that is autoimmune, which they've determined isn't the cause. How do they rule out other inflammatory conditions?

 

[Hip]

I basically have no autoimmune or bacterial reason for the inflammation. It's just there.

Have you considered whether your gastritis may be due to chronic enterovirus infection of the stomach, which John Chia's research found in 82% of ME/CFS patients?

My ME/CFS is most likely due to enterovirus (coxsackievirus B4 specifically), and one person who caught my ME/CFS-triggering virus from me developed gastritis. Several others who caught my virus developed recurrent stomach aches for several years.

In the stomach, enterovirus infects the parietal cells in the stomach lining (these are the cells which secrete hydrochloric acid for digestion purposes; they also produce intrinsic factor, a protein essential for vitamin B12 absorption).

Have you been tested for enterovirus using either Chia's stomach biopsy test, or by the sensitive ARUP lab antibody neutralization tests (other blood tests may not be sensitive enough to detect chronic enterovirus)?

Dr Chia's treatment for enterovirus includes oxymatrine and the antiviral Epivir.

 

[Galixie]

Have you considered whether your gastritis may be due to chronic enterovirus infection of the stomach, which John Chia's research found in 82% of ME/CFS patients?

My ME/CFS is most likely due to enterovirus (coxsackievirus B4 specifically), and one person who caught my ME/CFS-triggering virus from me developed gastritis. Several others who caught my virus developed recurrent stomach aches for several years.

In the stomach, enterovirus infects the parietal cells in the stomach lining (these are the cells which secrete hydrochloric acid for digestion purposes; they also produce intrinsic factor, a protein essential for vitamin B12 absorption).

Have you been tested for enterovirus using either Chia's stomach biopsy test, or by the sensitive ARUP lab antibody neutralization tests (other blood tests may not be sensitive enough to detect chronic enterovirus)?

Dr Chia's treatment for enterovirus includes oxymatrine and the antiviral Epivir.

That's an intriguing possibility. I'm sure that specific test wasn't done. They only did standard tests on the biopsies.

I'm not sure if it fits, but I'm willing to bring it up with my doctor. In my case I perpetually test strongly positive for EBV antibodies but no EBV DNA is detectable in the blood. Previous antiviral drugs had no discernable effect (the stomach issues were not a problem at the time). The fact that no one has ever caught a mono-like virus from me, makes me think it is a bit of a long shot though.

 

[Hip]

In my case I perpetually test strongly positive for EBV antibodies but no EBV DNA is detectable in the blood.

That's the norm in ME/CFS: high IgG antibody titers but typically negative by blood PCR. This may be because the infection is in the tissues rather than the blood (see for example Dr Lerner's abortive infection theory of ME/CFS, and the non-cytolytic enterovirus theory of ME/CFS).

There is also one study that suggested some subtypes of ME/CFS may be due to partial reactivation of Epstein-Barr virus. Refs: 1 2 EBV has 3 latency states: in the deepest state of latency (latency I) no viral proteins are produced; but in the two other states of latency (latency I and III), although the virus is still not fully reactivated, some EBV viral proteins are manufactured, as EBV partially awakens. So in ME/CFS, EBV may have partially awaken inside the cells.


Regular doctors and infectious disease specialists will ignore high IgG titers if the blood PCR is negative, but ME/CFS specialists usually take the opposite view, and see high titers as evidence of an active infection somewhere in the body. Dr Lerner would diagnosed active EBV in ME/CFS when there are elevated antibodies in the EBV IgM VCA test, and/or in the EBV EA diffuse test by ELISA.

You might find the viral testing details in this mini roadmap of interest.

 

[Seven7]

. I think, in my case, chrons is already ruled out because that is autoimmune,

Colitis is the same as Chrons but indifferent place. I do not have autoimune general
Markers so not sure I understand if you are saying you cannot have Chronsbecuase your autoimmune markers were negative?
They know by the samples of the gut they take. If there is imflamtion then you have an inflammatory gut disease, since they have no tests, mostlyi think y symptoms and the place where the inflammation was found.

 

[Galixie]

I'm getting the impression that my doubts about inflammation alone being able to cause nutrient deficiency are being confirmed.

It seems like there has to be some other mechanism at work such as atrophy, bacteria, or parasite.

The problem is that I've been told that I don't have any of those mechanisms. I would need something very compelling (medical articles of possible alternate diagnosis) to get any more testing done.

 

[Hip]

See this https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835780/