Need input with the results analysis
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taniaaust1
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oh wow 5 double copies and one being the worst kind of MTHFR mutation. I think that's the worst methylation results Ive seen. At least you have stuff you can work on now and at least will probably help some esp that MTHFR mutation. Was that run throu genetic genie? is there a report under these results on how to try to treat?
I suggest you to read the info at http://mthfr.net/ for expert advice. You will need the methyl B12 and active folate as your body cant convert. This not only will make your existing ME/CFS worst in many ways but also puts you at risk for strokes, heart issues and miscarriages (which all may be preventable with right treatment for MTHFR).
My MTHFR specialist has me on "Mega Folinic" from source naturals and High Potency Methylcobalamin B12 from Natural Factors for this (I take that last one under my tongue, it dissolves fast). Note.. supplments may not help right away and it may take a while for you to notice what they are doing (or it may not). As my MTHFR specialist said to me.. dont forget that your body has never worked right with this issue so can take time.
Treating my MTHFR has certainly helped give me less tiredness (wake up less tired) and also is one of only two things in the 17 years since I first got ill, which helped increase my endurance level.
Maybe with as many methylation isses as you have, it may be a good idea to see if you can find an expert in methylation to consult with.
I suggest you to read the info at http://mthfr.net/ for expert advice. You will need the methyl B12 and active folate as your body cant convert. This not only will make your existing ME/CFS worst in many ways but also puts you at risk for strokes, heart issues and miscarriages (which all may be preventable with right treatment for MTHFR).
My MTHFR specialist has me on "Mega Folinic" from source naturals and High Potency Methylcobalamin B12 from Natural Factors for this (I take that last one under my tongue, it dissolves fast). Note.. supplments may not help right away and it may take a while for you to notice what they are doing (or it may not). As my MTHFR specialist said to me.. dont forget that your body has never worked right with this issue so can take time.
Treating my MTHFR has certainly helped give me less tiredness (wake up less tired) and also is one of only two things in the 17 years since I first got ill, which helped increase my endurance level.
Maybe with as many methylation isses as you have, it may be a good idea to see if you can find an expert in methylation to consult with.
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minkeygirl
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@taniaaust1 I'm curious about your comment that the B12 dissolves fast. I thought, per Freddd it should take at least 45 minutes to dissolve.
Methylfolate with mthfr, mb12 is for mtrr where I am just hetero. What about COMT and MAO?
@Valentijn and @Critterina can you please offer me your input as well?
@Valentijn and @Critterina can you please offer me your input as well?
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@zzz0r - MTHFR C677T +/+ is a big problem - it means you produce methyfolate at 30% of the normal rate. Hence it's important to supplement methylfolate instead of folic acid, and it might be helpful to avoid folic acid.
MTRR A664A has a very small impact, maybe no impact at all when heterozygous. So there's no indication in your results that you would need to supplement B12.
However some people try B12 anyhow, in which case you might want to avoid methylB12 due to having the slow versions of MAOA, VDR, and COMT.
BHMT-02 can be ignored since there's no research showing that it has any impact on function. BHMT-08 is reported backwards, hence you have the good version.
MTRR A664A has a very small impact, maybe no impact at all when heterozygous. So there's no indication in your results that you would need to supplement B12.
However some people try B12 anyhow, in which case you might want to avoid methylB12 due to having the slow versions of MAOA, VDR, and COMT.
BHMT-02 can be ignored since there's no research showing that it has any impact on function. BHMT-08 is reported backwards, hence you have the good version.
Thank you @Valentijn . Would you think that I have to do anythhing with COMT or is it cancled out with VDR? Should I try forcing dopamine uptake? (I do have restless leg syndrome).
Also I knew that I would have severe deffeciency due to MTHFR before I sent the saliva specimen to 23andme as thanks to Feddds guide I could recognize methylfolate deffeciency symptoms. The appropriate dosage for me was found to be by titrating somewhere around 3mg to keep me out of symptoms. That dosage would make me nervous tho and very anrgy. Maybe it was the fact that I was taking that with 5mcg mb12, so if i try that without the mb12 or just minimize the dosage of mb12 in order to reduce the methylgroups intake, could make methylfolate more tolerable.
Also I knew that I would have severe deffeciency due to MTHFR before I sent the saliva specimen to 23andme as thanks to Feddds guide I could recognize methylfolate deffeciency symptoms. The appropriate dosage for me was found to be by titrating somewhere around 3mg to keep me out of symptoms. That dosage would make me nervous tho and very anrgy. Maybe it was the fact that I was taking that with 5mcg mb12, so if i try that without the mb12 or just minimize the dosage of mb12 in order to reduce the methylgroups intake, could make methylfolate more tolerable.
If both the formation and breakdown of neurotransmitters are slow, then that shouldn't be causing an imbalance. If you want to know more about your neurotransmitter levels, you should probably got those directly tested instead of guessing based on a couple SNPs.
Regarding B12, if methylB12 is causing you some problems then hydroxoB12 might work better. Or with less B12.
caledonia
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First Priority mutations: Unfortunately, 23andme is not testing SHMT any more, so I can't tell if you have that. You don't have ACAT or CBS issues to deal with. So unless you have gut issues, you can probably dive right into MTHFR. If you do have gut issues like leaky gut, then treat that first. You could try some folinic acid to see if that helped (SHMT being one of the "leaky gut" genes, and folinic being the workaround for it).
Second Priority mutations: You have a double mutation for MTHFR C677T, which is the major one, so definitely some methylfolate for that. Like Valentijn mentioned, it would be a good idea to avoid "folic acid" which is commonly added to supplements and foods, especially grains, cereals, and breads.
You only have one B12 mutation, which one of the minor MTRRs (B12 recycling). You may or may not need B12 supplementation. This is where you would want to go by symptoms or functional testing to see if you really need B12. Having metals such as mercury or lead could also lower B12, and may make supplementation necessary at least until the metals come out. This is a good article on B12 deficiency and risk factors for it: http://chriskresser.com/b12-deficiency-a-silent-epidemic-with-serious-consequences
http://chriskresser.com/b12-deficiency-a-silent-epidemic-with-serious-consequences
For your COMT/VDR combo, which is the second most sensitive one, Yasko suggests hydroxycobalamin and adenosylcobalamin. If you took methylcobalamin, or otherwise get too many methyl groups, you may get mood swings, as you've already reported. So low and slow is the way to go.
23andme doesn't report one of the BHMTs any more. Usually if you have a couple, you would have all three. BHMT is the secondary methylation pathway, so Yasko suggests some sunflower lecithin to get some TMG for that. That's another methyl donor, so you would want to take it easy.
For VDR Bsm, get your vitamin D checked and supplement if that's low. For the MAO A, Yasko suggests waiting until you have the rest of the methylation supplements on board and working well, then if you're still having mental health type problems, to add small sprinkles of 5htp (for serotonin).
Be sure to read the "Start Low and Go Slow" and "Roadblocks to Successful Methylation" documents linked in my signature before beginning.
Second Priority mutations: You have a double mutation for MTHFR C677T, which is the major one, so definitely some methylfolate for that. Like Valentijn mentioned, it would be a good idea to avoid "folic acid" which is commonly added to supplements and foods, especially grains, cereals, and breads.
You only have one B12 mutation, which one of the minor MTRRs (B12 recycling). You may or may not need B12 supplementation. This is where you would want to go by symptoms or functional testing to see if you really need B12. Having metals such as mercury or lead could also lower B12, and may make supplementation necessary at least until the metals come out. This is a good article on B12 deficiency and risk factors for it: http://chriskresser.com/b12-deficiency-a-silent-epidemic-with-serious-consequences
http://chriskresser.com/b12-deficiency-a-silent-epidemic-with-serious-consequences
For your COMT/VDR combo, which is the second most sensitive one, Yasko suggests hydroxycobalamin and adenosylcobalamin. If you took methylcobalamin, or otherwise get too many methyl groups, you may get mood swings, as you've already reported. So low and slow is the way to go.
23andme doesn't report one of the BHMTs any more. Usually if you have a couple, you would have all three. BHMT is the secondary methylation pathway, so Yasko suggests some sunflower lecithin to get some TMG for that. That's another methyl donor, so you would want to take it easy.
For VDR Bsm, get your vitamin D checked and supplement if that's low. For the MAO A, Yasko suggests waiting until you have the rest of the methylation supplements on board and working well, then if you're still having mental health type problems, to add small sprinkles of 5htp (for serotonin).
Be sure to read the "Start Low and Go Slow" and "Roadblocks to Successful Methylation" documents linked in my signature before beginning.
Sea
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Even if your snps do not indicate an increased need for B12 it is not wise to take Methylfolate without also taking B12. The Methylfolate can mask a B12 deficiency such that neurological damage can occur but the usual tests that would pick up a deficiency (high MCV) are normal
Thank you all for your input. And thank you @caledonia . Regarding COMT i thought it slows down the break down of dopamine and I was expecting for some to suggest a way to increase dopamine break down.
I am already taking adenob12 and I am seeing a huge increase i muscle. Does any one else experiences that?
I am already taking adenob12 and I am seeing a huge increase i muscle. Does any one else experiences that?
caledonia
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I haven't heard of a way to break down dopamine faster. Breaking down dopamine uses up methyl groups. So if your dopamine breaks down slowly, then you don't need as many methyl groups.
I'm taking adeno, but not very much, so I haven't seen the muscle building effect. I would love to have some muscle again!
Freddd has reported having more muscle and less fat. I don't know if he would attribute it to just adeno though - just to his overall program.