NAC adverse effects

[bad1080]

i have some of the adverse effects mentioned here: https://www.drugs.com/sfx/nac-side-effects.html
namely: swelling of the eyes and i feel off (maybe covered under "mild nausea")
i tried it before but i don't remember why i stopped taking it.

could this be an initial reaction that'd get better over time or would you discontinue?

edit:
i added a poll to the thread, it'd be much appreciated if you'd take part in it if you tried NAC. it's up to two votes (one for "yes" and one for what you did after having side-effects, or just one for "no"), thanks in advance!

i repeat: Multiple votes are allowed.

a general overview of NAC:
N-Acetylcysteine (NAC): Impacts on Human Health
https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/

 

[Rufous McKinney]

swelling of the eyes

NAC gets detox pathways going (in theory).

I experience swollen eyes and blurred vision much of the time and it worsens whenever I launch something that might lead to detox. My right eye gets it really intensely, as my right side is far sicker and that may also include the fact the liver is on the right side also.

 

[bad1080]

NAC gets detox pathways going (in theory).

I experience swollen eyes and blurred vision much of the time and it worsens whenever I launch something that might lead to detox. My right eye gets it really intensely, as my right side is far sicker and that may also include the fact the liver is on the right side also.

thanks! did you stick with it? maybe i try lowering the dose...

Microbiological use
Acetylcysteine can be used in Petroff's method of liquefaction and decontamination of sputum, in preparation for recovery of mycobacterium.[45] It also displays significant antiviral activity against influenza A viruses.[46]

Acetylcysteine has bactericidal properties and breaks down bacterial biofilms of clinically relevant pathogens including Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Enterobacter cloacae, Staphylococcus epidermidis, and Klebsiella pneumoniae.[47]

https://en.wikipedia.org/wiki/Acetylcysteine

 

[linusbert]

aaah shit, and i already did order glynac. glycine+n-acetyl-cystein.
i have really eye issues lately, do not want to aggravate.
but i also noticed that everything which is supposed to make it better, makes it worse, like ascorbic acid, lutein, zeaxanthine, the wild berrys.

Cystein is a sulfur compound, so if you have a problem with sulfur you got a problem with cystein and also glutathione possibly i imagine.
you might try the non acteyl version, just cystein, see if this is also a problem.
molybdenum might help with sulfur metabolism.

 

[Carl]

thanks! did you stick with it? maybe i try lowering the dose...

Microbiological use
Acetylcysteine can be used in Petroff's method of liquefaction and decontamination of sputum, in preparation for recovery of mycobacterium.[45] It also displays significant antiviral activity against influenza A viruses.[46]

Acetylcysteine has bactericidal properties and breaks down bacterial biofilms of clinically relevant pathogens including Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Enterobacter cloacae, Staphylococcus epidermidis, and Klebsiella pneumoniae.[47]

https://en.wikipedia.org/wiki/Acetylcysteine

Without knowing, you posted one reason why it can be a problem for many people.

aaah shit, and i already did order glynac. glycine+n-acetyl-cystein.
i have really eye issues lately, do not want to aggravate.
but i also noticed that everything which is supposed to make it better, makes it worse, like ascorbic acid, lutein, zeaxanthine, the wild berrys.

S-Acetyl-L-Glutathione might be helpful because it raises glutathione without causing the problems that NAC can cause, especially NAC's effect on the cause of ME, pathogenic biofilm(s). The only problem is it's a bit expensive. 50 grams cost me £76 and that was at half price....

 

[Rufous McKinney]

thanks! did you stick with it? maybe i try lowering the dose...

yes- I've got to get to the other side of this detoxing somehow.

My lymphatics are very stagnant, and I"ve processed a large amount of that in past weeks. I was attributing this improvement to the plasmalogens I was trying, but I did take the whole bottle of NAC at the same time.

Maybe both things helped that. Assuming I feel less swollen lymph nodes, I figure that is a good sign, (and given I have N-H Lymphoma as well).

 

[Rufous McKinney]

Without knowing, you posted one reason why it can be a problem for many people.

add: biofilm breakdown. Lots of goodies stored up there, I suspect.

 

[Rufous McKinney]

Reading about biofilms, I failed to consider they can be beneficial. Good biofilm. Bad biofilm.

Clearly I do not understand biofilms.

 

[bad1080]

add: biofilm breakdown. Lots of goodies stored up there, I suspect.

how long has it been and do you still get the side-effects? did you adjust the dose at all and did it help?

Reading about biofilms, I failed to consider they can be beneficial. Good biofilm. Bad biofilm.

i guess it depends on what created the biofilm and why

 

[bad1080]

Cystein is a sulfur compound, so if you have a problem with sulfur you got a problem with cystein and also glutathione possibly i imagine.

i tried MSM (methylsulfonylmethane) once and that gave me sulfur farts like crazy, idk if that's an indication

i have really eye issues lately, do not want to aggravate.

it's not said just because i have issues you will have the same issues but better keep an eye on it (no pun intended)

 

[Carl]

how long has it been and do you still get the side-effects? did you adjust the dose at all and did it help?


i guess it depends on what created the biofilm and why

More importantly is where. There are places where there shouldn't be biofilms because when there are, they are an attack against the vagus nerve which affects the digestive permeability of multiple places. That includes the colon where LPS is absorbed promoting even more inflammation along with the autoimmune problems that goes along with them.

 

[bad1080]

they are an attack against the vagus nerve which affects the digestive permeability of multiple places.

interesting, is there further reading you can point me to?

 

[linusbert]

i just remembered that also in Freddds Methylation Protocol he recommends not to take glutathion or any glutathion precursors even whey.

 

[bad1080]

Pharmacokinetics
The oral bioavailability of acetylcysteine is relatively low due to extensive first-pass metabolism in the gut wall and liver. It ranges between 6% and 10%.

https://en.wikipedia.org/wiki/Acetylcysteine

so 90% never made it into my system and i still got that kind of reaction? that's wild...

https://en.wikipedia.org/wiki/First_pass_effect

 

[Rufous McKinney]

how long has it been and do you still get the side-effects

I am too TIRED to figure this out. (oh, wait this is NOT the thread for moaning)

I had one bottle of -acetyl cysteine and I took one per day for 30 days. Now I"ve run out, need to order more and only now considered that: maybe that ALSO is contributing to buzzing brain and all the rest of it.

I figure it could take some time to detect improvements with the plasmalogens, (taken for about 2-3 months) and it make sense to me that they should HELP the cell membranes. And nothing works if your cell membranes are not operating well.

so next I ran out of Omega 3 itself, I'm using a local HEMP seed product (3-6-9).

 

[linusbert]

when the purpose of NAC is glutathione production, you also need the other precursors, the other limiting amino acid is glycine. so take both, like in a GlyNAC supplement.

the limiting precursors for glutathione are:
- primary cysteine
- followed by glycine
- glutamate / glutamine (usually not limiting in normal people but for chronic sick can be too)
- atp , now that sucks because we probably got too less of it. so if ATP is limiting it makes sense when giving precursors of glutathione increases synthesis of glutathione increases demands of ATP, leading to more ATP deficiency when low. BUT on the other side, glutathione might increase ATP production in the long run.

AI said it this way:

Spoiler

The synthesis of glutathione (GSH) depends on the availability of three amino acid precursors and enzymatic activity. The limiting precursors are:

1. Cysteine (primary limiting precursor):
   • It is the rarest of the three amino acids required and usually rate-limiting in glutathione synthesis under physiological conditions.
   • Its intracellular concentration is low, and its uptake is tightly regulated.
2. Glutamate:
   • Abundant in most cells, not typically limiting under normal conditions.
   • However, its availability can become limiting under certain metabolic or pathological states (e.g. glutamine deficiency or oxidative stress).
3. Glycine:
   • Usually not limiting, but in certain conditions such as liver disease, cancer, or high demand states, glycine can become relatively deficient.

Additional factors that may limit GSH synthesis:

• ATP availability: Required for both enzymatic steps of glutathione biosynthesis.
• Activity of key enzymes:
  • Glutamate-cysteine ligase (GCL) – rate-limiting enzyme.
  • Glutathione synthetase – second step enzyme.
• Redox status: Oxidative stress can increase demand and alter synthesis regulation.

In summary, cysteine is typically the primary limiting precursor in glutathione biosynthesis.

 

[LINE]

NAC or glutathione is a strong antioxidant with an affinity for the liver which stores toxins. I can say with certainty that if you detox the liver, you are going to have fallout. Using a binder will help remove the toxins effectively, otherwise, the toxins will just recirculate (at least a portion).

Good binders include Sonnes # 7 which is a bentonite clay ($30), chlorella (buy organic), activated charcoal is another good one, brown seaweed capsules. Zeolite is another good one, it is a clay similar to Sonnes.

NAC will release or mobilize toxins, binders bind the toxins for safe removal.

 

[bad1080]

Good binders include Sonnes # 7 which is a bentonite clay ($30), chlorella (buy organic), activated charcoal is another good one, brown seaweed capsules. Zeolite is another good one, it is a clay similar to Sonnes.

thanks, i am going to buy some healing clay.

 

[LINE]

Also, make sure you are taking the complimentary nutrients that allow NAC to complete its cycle, Life Force from Source Naturals is an excellent multi at a very good price.

 

[LINE]

thanks, i am going to buy some healing clay.

Make sure it is the right clays - I can give you links to trusted products if you like.