Primary Immunodeficiency just means you inherited a faulty immune system rather than acquired it through say a virus.I think chromosome 6 maybe important because it is where the HLA human leukocyte antigen gene complex is found,also I have a rare disorder on that chromosome,there is a mention of Ehler Danlos also,and its thought to be implicated in MS and Schizophrenia.Ive seen a study suggesting minocycline an antibiotic maybe able to calm microglial activation.Ive seen this mentioned in MS and Autism circles too