MTHFR Mutation.

[Ema]

I have been trying to figure out if my results from 23andme indicate a MTHFR mutation...but I have no idea what I am looking at/for. Does anyone know exactly which areas provide this information? I would really appreciate any help! Thanks, Ema


Gene Position SNP Versions Genotype
C1orf167, MTHFR 11768785 rs15854 A or G AA
C1orf167, MTHFR 11768839 rs4846048 A or G AG
C1orf167, MTHFR 11768857 rs1057624 C or T TT
C1orf167, MTHFR 11769034 rs4845884 A or G AA
C1orf167, MTHFR 11770023 rs2184226 C or T TT
C1orf167, MTHFR 11770036 rs3737967 A or G GG
C1orf167, MTHFR 11770329 rs28484963 G or T TT
C1orf167, MTHFR 11770346 rs3737966 C or T CT
C1orf167, MTHFR 11770448 rs1537516 A or G GG
C1orf167, MTHFR 11770489 rs1537515 A or C CC
C1orf167, MTHFR 11770641 rs34733339 C or T TT
C1orf167, MTHFR 11771466 rs2077360 A or G GG
C1orf167, MTHFR 11772034 rs868014 A or G GG
C1orf167, MTHFR 11772952 rs4846049 G or T GT
MTHFR 11773337 rs35737219 A or G GG
MTHFR 11773514 rs2274976 C or T CC
MTHFR 11773705 rs7518348 A or G GG
MTHFR 11773860 rs45590836 C or T CC
MTHFR 11773906 rs2274974 C or T CC
MTHFR 11774697 rs13306556 C or T CC
MTHFR 11774887 rs1476413 C or T CT
MTHFR 11777044 rs4846051 A or G AA
MTHFR 11777063 rs1801131 G or T GT
MTHFR 11777080 rs3927589 A or C CC
MTHFR 11777258 rs12121543 A or C AC
MTHFR 11777342 rs1994798 A or G AG
MTHFR 11777410 i5003528 A or G GG
MTHFR 11777513 rs2066464 C or T TT
MTHFR 11777758 i5003529 A or C AA
MTHFR 11777802 i5003530 C or T TT
MTHFR 11777805 i5003527 A or G AA
MTHFR 11777828 rs6664734 C or T CC
MTHFR 11777867 rs13306555 A or G GG
MTHFR 11778454 rs6541003 A or G AG
MTHFR 11778922 rs34279942 A or G GG
MTHFR 11778965 rs1801133 A or G GG
MTHFR 11779024 rs13306554 A or G GG
MTHFR 11779434 rs17421462 A or G GG
MTHFR 11780298 rs1572151 C or T TT
MTHFR 11780538 rs4846052 C or T CT
MTHFR 11782894 i5003531 C or T CC
MTHFR 11783430 rs17037390 A or G GG
MTHFR 11783863 rs2066466 C or T CC
MTHFR 11783880 rs45550133 A or G GG
MTHFR 11783935 rs2066461 G or T GG
MTHFR 11784634 rs17037396 C or T CC
MTHFR 11784750 rs17037397 A or C CC
MTHFR 11784801 rs9651118 C or T CT
MTHFR 11785365 rs17367504 A or G AA
MTHFR 11785522 rs1413355 C or T TT
MTHFR 11785558 rs2066472 C or T CC
MTHFR 11785644 rs2066470 A or G GG
MTHFR 11785782 rs34889587 A or G GG
MTHFR 11785864 rs17037404 A or G GG
MTHFR 11786561 rs1931226 A or C CC
MTHFR 11786736 rs7553194 A or G GG
MTHFR 11787173 rs3753584 C or T TT
MTHFR 11787837 rs3753583 A or G GG
MTHFR 11788391 rs13306561 A or G AA
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[richvank]

Hi, Ema.

The way I read it is that you don't have the MTHFR C677T polymorphism, you have one copy, (+/- or heterozygous) for MTHFR A1298T, and you do not have the MTHFR 03 polymorphism that Amy Yasko also characterizes. Will someone check me to make sure I've done it right?

Rich

P.S. MTHFR C677T is rs1801133, MTHFR A1298C is rs1801131, and MTHFR 03 is rs2066470.

 

[Ema]

Thank you for your help!

So does this mean that I should be able to tolerate the folic acid in the Jarrow B-Right?

I'm trying to get started on the methylation protocol and must admit to being very confused and without a clear plan (which is unlike me typically).

So far I am taking:

Jarrow B-Right, 1x/day
Jarrow Methyl B12 lozenge, 1x/day held under tongue for 45-60 min
Active Folate, 800 mcg

I have the adB12 from Source Naturals but have not started it yet.

I don't know when to start it or really how much I should aim for of the others though I do know that I am not taking enough of them either. Any help figuring target dosages would be greatly appreciated.

I have been doing these three for about 2 weeks and I am starting to feel worse...intensification of symptoms (fatigue, nausea, blurry vision, headaches, anxiety) which did lead me to abandon the protocol about this same time last year. This time I am more determined to make it through the start up but am worried.

I also take phosphatidylcholine, KDur, CoQ10, Vit D, Alpha Lipoic Acid, Hydrocortisone, T3, sex hormones, ProBoost, Vit C, and topical magnesium. I've done all of these for the past year(s) without any problems (or significant improvement unfortunately). I've also been diagnosed with Lyme and take antibiotics for that.

Also, in the PS you refer to MTHFR A1298C but in the main part of the post you mention that I am heterozygous for MTHFR A1298T...should this be the same thing (ie typo?)?

Thanks again for the help!

 

[richvank]

***Hi, Ema.

Thank you for your help!

***You're welcome.

So does this mean that I should be able to tolerate the folic acid in the Jarrow B-Right?

***That doesn't depend on the MTHFR SNPs, as far as I know. It may be dependent on SNPs in DHFR, but we don't know which ones yet. It may also depend on your level of NADPH, which can be measured, but usually isn't.

I'm trying to get started on the methylation protocol and must admit to being very confused and without a clear plan (which is unlike me typically).

***Well, you aren't alone. There is still a lot that is not known, and we are not all in agreement about it yet.

So far I am taking:

Jarrow B-Right, 1x/day
Jarrow Methyl B12 lozenge, 1x/day held under tongue for 45-60 min
Active Folate, 800 mcg

I have the adB12 from Source Naturals but have not started it ye

I don't know when to start it or really how much I should aim for of the others though I do know that I am not taking enough of them either. Any help figuring target dosages would be greatly appreciated.

I have been doing these three for about 2 weeks and I am starting to feel worse...intensification of symptoms (fatigue, nausea, blurry vision, headaches, anxiety) which did lead me to abandon the protocol about this same time last year. This time I am more determined to make it through the start up but am worried.

***This sounds like Freddd's protocol, so you should probably get dosage advice from him. He generally favors higher dosages than I do, and he also generally favors continuing the protocol and pushing through when the symptoms rise, while I favor doing only what you feel you can tolerate.

I also take phosphatidylcholine, KDur, CoQ10, Vit D, Alpha Lipoic Acid, Hydrocortisone, T3, sex hormones, ProBoost, Vit C, and topical magnesium. I've done all of these for the past year(s) without any problems (or significant improvement unfortunately). I've also been diagnosed with Lyme and take antibiotics for that.

Also, in the PS you refer to MTHFR A1298C but in the main part of the post you mention that I am heterozygous for MTHFR A1298T...should this be the same thing (ie typo?)?

***Sorry, yes, I mistyped. It should be a C.

Thanks again for the help!

***O.K. Best regards,

***Rich