MS May Develop in Lymph Nodes

[Marco]

I'm not sure I understand the full title of this article but it appears that aberrant B cells in the brain, that may contribute to the disease, get their initial 'programming' in the lymph nodes with the potential for 'peripheral' treatment options.

“This helps explain why treatments that work outside the central nervous system can ease MS symptoms and may give us clues how to develop even more effective treatments,” Kevin O’Connor, one of the paper’s senior authors, said in a statement.

http://www.hcplive.com/articles/MS-May-Develop-in-Lymph-Nodes-Not-Autoimmune-System

 

[Bob]

I wonder if they've tested Rituximab (or similar) on MS patients.

 

[Gemini]

I wonder if they've tested Rituximab (or similar) on MS patients.

Yes, apparently quite effectively....

http://www.ncbi.nlm.nih.gov/pubmed/24928997

and.....

http://www.ncbi.nlm.nih.gov/pubmed/18272891

but...

http://www.ncbi.nlm.nih.gov/pubmed/24310855