Metabolic rescue of α-synuclein-induced neurodegeneration through propionate supplementation and intestine-neuron signaling in C. elegans (Wang; 2/24)

[Mary]

More Parkinson's disease research:

https://www.msn.com/en-us/health/ot...S&cvid=a5b5a744217d475288cc3f10cec544c5&ei=98

https://www.cell.com/cell-reports/f...m/retrieve/pii/S2211124724001931?showall=true

Microbial metabolites that can modulate neurodegeneration are promising therapeutic targets. Here, we found that the short-chain fatty acid propionate protects against α-synuclein-induced neuronal death and locomotion defects in a Caenorhabditis elegans model of Parkinson’s disease (PD) through bidirectional regulation between the intestine and neurons. Both depletion of dietary vitamin B12, which induces propionate breakdown, and propionate supplementation suppress neurodegeneration and reverse PD-associated transcriptomic aberrations.

 

[linusbert]

so eating butter is kinda beneficial i guess, due to short chain fatty acids like propionate.