Learner1
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Just saw this today:
https://www.fiercebiotech.com/research/reviving-tired-t-cells-to-improve-immuno-oncology-treatments
https://www.fiercebiotech.com/research/reviving-tired-t-cells-to-improve-immuno-oncology-treatments
The Penn researchers discovered that the amount of TOX in a T cell orchestrates the body’s response to infections or cancer by controlling the balance of effector T cells and exhausted T cells. Furthermore, TOX shapes the cells’ genomes, making it difficult for some genes to produce proteins. That may explain why it’s so challenging to transform exhausted T cells into effector T cells,