ME/CFS stopped with outbreak of autoimmune disease

[vision blue]

One specific question i have is how about the *memory* symptom of CFS. Could you do a before/after short term memory test both when in a AI flare and when in a CFS "flare"? If you do, please PM me with results since those willl come to email and I may need to be off here again for a while. I'd like to know if that also improves during an AI flare.

i also have found distracting my immune system leads to systemic improvement and sometimes even when i injure a limb and it swells think of the positive side that it will mean a decrease in some other systemic symptoms. I always feel like i cycle between clusters of symptoms. and sometimes when paritculary bad, i wonder if i shoujld create something to give my immune system something better to do .

 

[Wishful]

I think oxidative stress in the skeletal muscles causes lipid peroxidative, damage to the cell membranes, and this causes the immune response in cfs , but it started with the oxidative stress in the muscles

There's also physical damage to the cells when you strain them beyond their present capability; you actually tear the cells apart. The immune system recognizes the fragments as foreign molecules and goes to work to clean them up. Likewise, the immune cells probably respond to the molecules and structures that leak out of the cell's interior. Oxidative stress in muscles might be one possible trigger for immune system activation, but it's by no means the only one.

 

[pattismith]

Hi!

I have been a mild case for many years. Then, two years ago, my psoriasis broke out (for the first time). Right after the beginning of the psoriasis my CFS/ME symptoms stopped. They came back a few months ago (while my psoriasis has gone). Now I'm moderate.

Does anyone have any idea why? I wonder if this is a sign for the condition being linked to the immune system. Kind of a proof?

Thank you all!

Here another interesting article on the shift from allergy to psoriasis with Il-13 inhibition;
Could it be that your ME-CFS is associated with IL-13 activation? In that case an IL-13 inhibitor may be helpful?

IL-13 INHIBITION USED FOR ATOPIC DISEASES IS ASSOCIATED WITH RISK OF PSORIATIC ARTHRITIS

UK 2023

Conclusion Genetically proxied IL-13 inhibition is associated with increased risk of PsA, psoriasis and Crohn’s disease, which may be a class effect relevant to other IL-13i that are not yet reported to have Th17-type adverse events. These findings are compatible with the hypothesis that Th2 cytokines IL-4/-13 may act as a restraint toward Th17-type disease activation in some organs. Clinicians assessing adverse events after dupilumab initiation should be aware of incident PsA and related features. This study demonstrates the value of genetic instrumental variable analyses in evaluating rare adverse events in the study of drug safety.

 

[triffid113]

Interesting. Well I know the body can only make so many inflammatory cytokines per day, which seems to me to indicate that your ME/CFS is not able to manifest without inflammation. I wonder if other anti-inflammatories would have a similar effect?

 

[triffid113]

So, for instance, try taking enough omega-3 to use up total cytokine capacity making non-inflammatory cytokines, leaving no ability to make inflammatory cytokines. (Per OmegaRX by Dr. Barry Sears). I don’t remember - might take 11g. I did this to treat allergies… can’t remember - may take 3 days to take effect - once you use up the cytokine capacity, you may need somewhat less. It works to stop allergies. If it works the same as psoriasis for you, then inflammation is the key problem.

 

[triffid113]

Um , dunno if IL -13 is an inflammatory cytokine. High dose omega 3 did not cause psoriasis for me though. However after a year it exceeded my gut tolerance. It was a great year.