@Justin30 , I cannot speak to the biggest, most active Lyme forums, but I am happy to share with you the three I prefer. They are each different from the other.
Lymenet Europe - heavy on TBD theory and politics.
Lymenet Flash - heavily ILADS slanted and treatment-centric (much of it alternative)
MD Junction - I havent been on recently, but they were a good mixture, I thought.