Jared Younger video “Will nalfemene be better than naltrexone (LDN) for neuro-inflammation?”

[dankeen]

He discusses it in this Youtube video
The chemical structures are very similar.
Potential advantages over LDN
1) improved half-life
2) improved bioavailability
3) improved tolerability
4) several times more effective at blocking TLR4. This may mean it is more effective if that is the mechanism although I am not sure that anyone really knows.

It is available on Indiamart (branded so produced to western standards) as Selincro. It costs about $35 for 14x 18mg + postage. It is also available on goldpharma for three times the price.

LDN is typically dosed around 5mg which is 10% of the standard dose for addiction. Extrapolating from this then I estimate a low dose of Selincro is about 1.8mg, but as always start low and titrate slowly to reduce the risk of side effects.

I am not expecting any miracles because LDN is only marginally effective for most responders.
For what it costs then I think it is worth trying in the hope that it is slightly more effective and/or may be tolerated by some people who cannot tolerate LDN.

 

[junkcrap50]

I saw the article on HealthRising about Younger & Nalmefene. I'm thinking of doing the same thing and trying it too.

It's water soluble, so you can dilute it in water like people do with LDN. So it would be easy to dose.

You might consider comparing the half life of Naltrexone vs Nalmefene when estimating a dose. And the excretion half-life is different than brain receptor occupancy half-life for both drugs. I haven't tried to figure out how to compare the two, but it may be useful since LDN is meant to give short term opioid receptor blockade to allow a rebound of national opioids.

Then again, starting very low like 1% and going up slowly would probably be simplest.