Ecoclimber
Senior Member
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FYI
https://www.nejm.org/doi/full/10.1056/NEJMoa2001191?query=featured_home
Washington State at Providence Hospital in Everett.
Summary
An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries.
We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient’s initial mild symptoms at presentation with progression to pneumonia on day 9 of illness.
This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection...
Much of the information being release on 2019nCoV has NOT been peer review so speculative conjecture is assumed at this point and the situation remains very fluid.
FHCRC Fred Hutch
Again, there is absolutely no evidence for either (1) sequence insertions or (2) their relationship to HIV. If you'd like to look at the alignment yourself, I've posted it here: https://trvrb.s3.amazonaws.com/sars-like-spike-alignment.fasta…
This paper proposes that there are 4 short "insertions" in the spike protein in #nCoV2019 copied from HIV. Yesterday, I showed that the proposed inserts are tiny strings that randomly match a whole bunch of things. 2/9
Dr. Eric Feigl-Ding
@DrEricDing
Public health scientist
/ Epidemiologist / Health Economist / Harvard ‘07 + Johns Hopkins ‘04 /
First case was asymptomic around Dec 15 patient is deceased. The patient and other patients that were infected had never been near the market. Initial tests indicate that 2019nCoF strain was introduced into the market.
They also found their models suggest potentially earlier epidemic start date around Dec 1-15th fit their results the best. This is actually consistent with other previous @NEJM study
Finally, the authors estimated a fatality rate of the coronavirus to be around 6.5% (deaths so far mostly from Wuhan). They also provide comparisons to SARS, and forecasting into the future (very unpredictable - don’t rely on these alone, as others have different forecasts)
Please read first post above before continuing): The authors report an R0=4.08. They made many assumptions; and did some simulations, and still got the ~4.08 approximate value.
Treatment other than outlined in NEJM, was anecdotal report of Wuhan doctor recovering using Lopinavir, remdesivir, ritonavir n=1
First Case of 2019 Novel Coronavirus in the United States
https://www.nejm.org/doi/full/10.1056/NEJMoa2001191?query=featured_home
Washington State at Providence Hospital in Everett.
Summary
An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries.
We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient’s initial mild symptoms at presentation with progression to pneumonia on day 9 of illness.
This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection...
Much of the information being release on 2019nCoV has NOT been peer review so speculative conjecture is assumed at this point and the situation remains very fluid.
FHCRC Fred Hutch
Again, there is absolutely no evidence for either (1) sequence insertions or (2) their relationship to HIV. If you'd like to look at the alignment yourself, I've posted it here: https://trvrb.s3.amazonaws.com/sars-like-spike-alignment.fasta…
This paper proposes that there are 4 short "insertions" in the spike protein in #nCoV2019 copied from HIV. Yesterday, I showed that the proposed inserts are tiny strings that randomly match a whole bunch of things. 2/9
Dr. Eric Feigl-Ding
@DrEricDing
Public health scientist
/ Epidemiologist / Health Economist / Harvard ‘07 + Johns Hopkins ‘04 /
First case was asymptomic around Dec 15 patient is deceased. The patient and other patients that were infected had never been near the market. Initial tests indicate that 2019nCoF strain was introduced into the market.
They also found their models suggest potentially earlier epidemic start date around Dec 1-15th fit their results the best. This is actually consistent with other previous @NEJM study
Finally, the authors estimated a fatality rate of the coronavirus to be around 6.5% (deaths so far mostly from Wuhan). They also provide comparisons to SARS, and forecasting into the future (very unpredictable - don’t rely on these alone, as others have different forecasts)
Please read first post above before continuing): The authors report an R0=4.08. They made many assumptions; and did some simulations, and still got the ~4.08 approximate value.
Treatment other than outlined in NEJM, was anecdotal report of Wuhan doctor recovering using Lopinavir, remdesivir, ritonavir n=1