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Badpack, I wrote a more complete explanation , thread title -'' cancer metabolism, gene expression and enzyme expression in cfs skeletal muscle cell '' .
This mechanism is happening is muscle, brain, muscle and heart , its a cycle of increased oxidative stress , upregulated antioxidant system , altered gene and enzyme expression involved in glycolysis, antioxidant system and mitochondrial energy production. What started out as a defense to oxidative actually establishes a cycle of oxidative stress, because the expression levels of genes and enzymes has been altered to so much that it actually causes a increase in oxidative stress . The altered genes and enzyme expression increases the antioxidant defense and alters the energy production pathways, and the altered genes and enzyme expression also results in a higher level of oxidative stress. So the cfs patient is in a cycle of increased oxidative stress, upregulated antioxidant system and altered energy production pathways.
This is the same cycle is occurring in cancer cells , oxidative stress has been shown to be higher in cancer, and even trigger or initiate cancer. But i'm not suggesting cfs people are going to get cancer, at least not from this mechanism.
This mechanism is happening is muscle, brain, muscle and heart , its a cycle of increased oxidative stress , upregulated antioxidant system , altered gene and enzyme expression involved in glycolysis, antioxidant system and mitochondrial energy production. What started out as a defense to oxidative actually establishes a cycle of oxidative stress, because the expression levels of genes and enzymes has been altered to so much that it actually causes a increase in oxidative stress . The altered genes and enzyme expression increases the antioxidant defense and alters the energy production pathways, and the altered genes and enzyme expression also results in a higher level of oxidative stress. So the cfs patient is in a cycle of increased oxidative stress, upregulated antioxidant system and altered energy production pathways.
This is the same cycle is occurring in cancer cells , oxidative stress has been shown to be higher in cancer, and even trigger or initiate cancer. But i'm not suggesting cfs people are going to get cancer, at least not from this mechanism.