HSV1 HSV2 TRIGGER FACTORS FOR BEHCET DISEASE

[pattismith]

HERPES SIMPLEX - TRIGGER FACTOR FOR BEHCET DISEASE.​

• Source: Dermatovenerologia Journal . 2020, Vol. 65 Issue 2, p27-31. 5p.

• Abstract: Introduction:
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• Behcet's disease is a multisystemic inflammatory condition, with unknown etiology. Most common clinical manifestations include painful oral mucosa ulcerations, painful genital mucosa ulcerations, cutaneous lesions and ocular lesions.
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• Positive HLA-B51 antigen is a well-known risk factor. The etiopathogenesis of the disease includes bacterial, viral and environmental factors.
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• Case report: Wie report the case of a 24-year-old female patient, from urban area, who presented to our clinic for painful polymorphic cutaneo-mucosal lesions. Skin assessment revealed multiple painful oral and genital mucosa ulcerations, as well as upper chest pustules and pretybial bilateral subcutaneous nodules.
• Ophtalmological examination identified conjunctival hyperemia, right palpebral edema and photophobia. Laboratory findings revealed leukocytosis with neutrophilia, elevated erythrocite sedimentation rate (ESR) and positive rheumatoid factor (PR).
• Bacteriological and micological tests performed from the lesions were negative. Serological tests were performed and IgM anti herpes simplex virus type 1 (Ig M anti HSV-1) and IgM anti herpes simplex virus type 2 (IgM anti HSV-2) were identified. The patient followed systemic treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) and local treatment with a combination of steroidal and antibiotic cream. Clinical evolution was favorable, with complete resolution of lesions in approximatively 1 week.
• Conclusions: The possible viral etiology of Behcet's disease is a long investigated topic. Complete evaluation and multidisciplinary follow-up of these patients is vital in the approach of these cases.

https://web.s.ebscohost.com/abstrac...e&authtype=crawler&jrnl=12203734&AN=145451757

 

[pattismith]

AND a mouse model of Behcet Disease is induced by HSV1...

HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications. Review 2018

Herpes simplex virus (HSV) infection [3,4,5,6] is believed to be a triggering factor of BD. HSV-induced BD animal models have been shown to have similar inflammatory responses compared with BD patients, such as mucocutaneous, ocular, vascular, arthritic, and gastrointestinal involvement

 

[pattismith]

Lot's of infection can trigger Behcet Disease, here some recent articles

It is worth noting that Adamantiades-Behçet's disease is not an infectious disease [19].
However, bacterial and viral microorganisms can become triggers of the disease, especially Herpes simplex-1 virus, Streptococcus sanguis and Mycoplasma fermentas, which are considered the mostly studied organisms in the pathogenesis of Adamantiades-Behçet's disease.

The relationship between streptococcal infections and the disease is suggested by clinical observations of infections such as dental caries, periodontitis and tonsillitis.

In turn, Behçet suggested that herpes simplex virus is an etiological factor in the development of disease, as he noted that serum antibodies to HSV-1, as well as circulating immune complexes to HSV-1, were elevated in patients with Adamantiades-Behçet's disease. In addition, mice vaccinated against HSV-1 (30%) have developed symptoms similar to Adamantiades-Behçet's disease, including aphthous lesions in the oral cavity, skin, genital, and gastrointestinal ulcers, and eye inflammation and arthritis [26,27,28]. At last, Mycoplasma fermentas antibodies were detected in the circulation of approx. 1/3 of patients with Adamantiades-Behçet's disease but in none of matched age and sex controls

https://www.sciencedirect.com/science/article/pii/S0738081X23000809