Basilico
Florida
- Messages
- 948
My husband and I just came across this today; it sounds really interesting and potentially very useful, especially since we have not be able to do any strength training in a long time and we are both definitely losing muscles (an issue that I know affects many here). He suspects that I may have a bit of sarcopenia.
HMB (beta-Hydroxy beta-methylbutyric acid) is naturally produced in the human body, though it must be converted from L-Leucine and very little ends up making it's way into HMB.
There are no adverse effects reported in human studies where people took 3 grams/daily taken for a year.
The only mention I could find of HMB here on PR was using it for an unrelated purpose, and someone mentioned it affected cortisol levels, but I couldn't find any evidence to corroborate that assertion.
Has anyone heard of or used this? I just placed an order, will be starting it soon.
@antherder and @arewenearlythereyet and @Diwi9 and @Crux and @Hip , I saw you mentioned slow wound healing, this might be interesting for you to try if you haven't already.
Some interesting wikipedia quotes:
In healthy adults, supplementation with HMB has been shown to increase gains in muscle size, muscle strength, lean body mass, reduce skeletal muscle damage, and speed recovery from exercise.[2][8][9][10] HMB produces these effects in part by stimulating the production of proteins and inhibiting the breakdown of proteins in muscle tissue.[7][11][12]Medical reviews have found no issues with safety from long-term use as a dietary supplement in adults.[2][8][9][13]
And:
The effects of HMB on human skeletal muscle were first discovered by Steven L. Nissen at Iowa State University in the mid-1990s.[18][23] It is added to certain medical foods that are intended to provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS and to promote wound healing.
Some branded products that contain HMB (i.e., certain formulations of Ensure and Juven) are medical foods that are intended to be used to provide nutritional support under the care of a doctor in individuals with muscle wasting due to HIV/AIDS or cancer, to promote wound healing following surgery or injury, or when otherwise recommended by a medical professional.[1][18][24][25] Juven, a nutrition product which contains 3 grams of HMB-Ca, 14 grams of l-arginine, and 14 grams of l-glutamine per two servings,[1] has been shown to improve lean body mass during clinical trials in individuals with AIDS and cancer.
Supplemental HMB has been used in a number of clinical trials as a treatment for preserving lean body mass in muscle wasting conditions, particularly sarcopenia, and has been studied in clinical trials as an adjunct therapy in conjunction with resistance exercise.[7][8][15][11] HMB supplementation may also prevent muscle atrophy during bed rest, but more research is needed to determine its efficacy for this purpose.
https://en.wikipedia.org/wiki/Beta-Hydroxy_beta-methylbutyric_acid
HMB (beta-Hydroxy beta-methylbutyric acid) is naturally produced in the human body, though it must be converted from L-Leucine and very little ends up making it's way into HMB.
There are no adverse effects reported in human studies where people took 3 grams/daily taken for a year.
The only mention I could find of HMB here on PR was using it for an unrelated purpose, and someone mentioned it affected cortisol levels, but I couldn't find any evidence to corroborate that assertion.
Has anyone heard of or used this? I just placed an order, will be starting it soon.
@antherder and @arewenearlythereyet and @Diwi9 and @Crux and @Hip , I saw you mentioned slow wound healing, this might be interesting for you to try if you haven't already.
Some interesting wikipedia quotes:
In healthy adults, supplementation with HMB has been shown to increase gains in muscle size, muscle strength, lean body mass, reduce skeletal muscle damage, and speed recovery from exercise.[2][8][9][10] HMB produces these effects in part by stimulating the production of proteins and inhibiting the breakdown of proteins in muscle tissue.[7][11][12]Medical reviews have found no issues with safety from long-term use as a dietary supplement in adults.[2][8][9][13]
And:
The effects of HMB on human skeletal muscle were first discovered by Steven L. Nissen at Iowa State University in the mid-1990s.[18][23] It is added to certain medical foods that are intended to provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS and to promote wound healing.
Some branded products that contain HMB (i.e., certain formulations of Ensure and Juven) are medical foods that are intended to be used to provide nutritional support under the care of a doctor in individuals with muscle wasting due to HIV/AIDS or cancer, to promote wound healing following surgery or injury, or when otherwise recommended by a medical professional.[1][18][24][25] Juven, a nutrition product which contains 3 grams of HMB-Ca, 14 grams of l-arginine, and 14 grams of l-glutamine per two servings,[1] has been shown to improve lean body mass during clinical trials in individuals with AIDS and cancer.
Supplemental HMB has been used in a number of clinical trials as a treatment for preserving lean body mass in muscle wasting conditions, particularly sarcopenia, and has been studied in clinical trials as an adjunct therapy in conjunction with resistance exercise.[7][8][15][11] HMB supplementation may also prevent muscle atrophy during bed rest, but more research is needed to determine its efficacy for this purpose.
https://en.wikipedia.org/wiki/Beta-Hydroxy_beta-methylbutyric_acid
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