Hepcidin Increases Cytokines in Alzheimer’s Disease: Implication of Impaired Iron Homeostasis in Neuroinflammation

[pattismith]

Hepcidin Increases Cytokines in Alzheimer’s Disease and Down’s Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation​

https://www.frontiersin.org/articles/10.3389/fnagi.2021.653591/full

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A significant increase in serum hepcidin levels was found in DS, compared to controls and AD subjects (p < 0.0001).

Hepcidin protein was visible in the epithelial cells of choroid plexus, meningeal macrophages and in the astrocytes close to the endothelium of blood vessels. Hepcidin co-localized with IL-6, indicating its anti-inflammatory properties.

We found significant correlation between hypoferritinemia and elevated levels of serum hepcidin in AD and DS.

Hepcidin can be transported via macrophages and the majority of the vesicular hepcidin enters the brain via a compromised blood brain barrier (BBB).

Our findings provide further insight into the molecular implications of the altered iron metabolism in acute inflammation, and can aid towards the development of preventive strategies and novel treatments in the fight against neuroinflammation.

 

[pattismith]

This paper caught my interest because it makes a link between low ferritin, high hepcidin and neuroinflammation.

In many other papers, high hepcidin is usually associated with high inflammation and high inflammation with hyperferritinemia. (This is the usual explanation for inflammatory anemia)

I wonder how we can explain these two different pathologic phenomenon!


https://www.frontiersin.org/articles/10.3389/fimmu.2023.1110540/full