Glymphatic Pump Massage?

[bad1080]

i read a study about how a medication usually used to induce labor (iirc; i can't find said study rn, if you know which one i am talking about please lmk!) was successfully used in rats to improve the function of the glymphatic pumps (the brain's waste disposal system) and thus rejuvenate the "brain age" of the rats.

i guess PwME have a lot of brain-waste to dispose of so my question now is: has anybody tried messaging the region of the neck where the pumps are located? for me this would be below the ears and slightly to the rear of the neck. sometimes i get a sharp stabbing pain there (i then have to tilt my head and open my mouth for some relief) when i suspect the pumps are doing their job.

i tried rolling the region with a small massage/fasciae ball and it is quite painful even without much pressure but not long enough to tell if it makes a difference yet. i will continue and report back!

 

[Sizzle]

Dexmedetomidine ?

https://www.sciencedirect.com/science/article/pii/S0165614722002036

 

[bad1080]

Dexmedetomidine ?

https://www.sciencedirect.com/science/article/pii/S0165614722002036

thanks, that's interesting!

Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation.

from: https://en.wikipedia.org/wiki/Dexmedetomidine

but it sounds like the opposite of what i had in mind. i never heard of the drug when i read it but i am pretty sure it was something used to induce labor (i was curious if it was FDA approved, that's why i looked it up but i also could be misremembering).

 

[Algo]

Oxytocin?

 

[bad1080]

Oxytocin?

thanks! this might've been it:

Unlocking potential of oxytocin: improving intracranial lymphatic drainage for Alzheimer's disease treatment

from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11303076/

In 1909 the first clinical use of oxytocin was performed by William Blair-Bell to induce childbirth in patients with complications.[19][20]

from: https://en.wikipedia.org/wiki/Oxytocin

 

[Algo]

Nice!

 

[Springbok1988]

Prostaglandin F2α (PGF) is what I’ve seen in the literature lately. It’s used to induce labor and was recently found to aid in glymphatic drainage.

https://scholar.google.com/scholar?...ic+system&hl=en&as_sdt=0&as_vis=1&oi=scholart

 

[Rufous McKinney]

Prostaglandin F2α (PGF)

this does not seem to exist in a form anyone can purchase

 

[Rufous McKinney]

sometimes i get a sharp stabbing pain there

me too.
A bubble is often present on the right side of my neck. The right side of my lymphatic system is a mess.

 

[bad1080]

me too.
A bubble is often present on the right side of my neck. The right side of my lymphatic system is a mess.

not sure what you mean with "bubble" like a knot or something? have you found anything that helps?

 

[junkcrap50]

this does not seem to exist in a form anyone can purchase

Yes there is. Latanoprost is a common eye drop.

Other drug analogues exist too, such as Dinoprost and:

The following medications are analogues of prostaglandin F2α:

• Latanoprost
• Bimatoprost
• Travoprost
• Carboprost

https://en.wikipedia.org/wiki/Prostaglandin_F2alpha#Analogues

 

[bad1080]

i am suffering from a massive headache today (took two painkillers already and they did barely anything) and i am not sure if it is related to the massage or something else but headaches are usually rather uncommon for me (especially of this magnitude). the only other thing i can think of it's because of the prednisolone withdrawal (today is the 5th day off after taking it for a week)?

 

[Rufous McKinney]

brain-waste to dispose of so my question now is: has anybody tried messaging the region of the neck where the pumps are located?

I really need to get my glymphatic system flowing. I have a NHL diagnosis, also. So this news is exciting.

with "bubble" like a knot or something

I can't feel a knot there per se. it's like intense pressure, hence the term bubble. Usually short lived.

Perhaps it's related to wind, a chinese medicine term. Wind can blow in and blow out and move around.

 

[Rufous McKinney]

Yes there is. Latanoprost is a common eye drop.

thanks!

I'm convinced I have too much eye pressure but the eye doctors refused to test me.

Maybe I can get this somehow.

 

[bad1080]

I can't feel a knot there per se. it's like intense pressure, hence the term bubble. Usually short lived.

Perhaps it's related to wind, a chinese medicine term. Wind can blow in and blow out and move around.

gotcha, i think that's what i'm trying to mitigate with tilting my head and opening my mouth!

 

[Rufous McKinney]

i tried rolling the region with a small massage/fasciae ball and it is quite painful even without much pressure but not long enough to tell if it makes a difference yet. i will continue and report back!

I am trying to do more direct lymph massage, here. It seems like I can tolerate about one minutes worth of doing this.

The neck area is very congested. Full of anatomy that is complaining alot.

 

[bad1080]

finding the tender areas seems to be much easier with the ball.
and i think my headache was potassium related (even though i didn't do any B12) it finally got better after taking some.