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(WO/2006/110589) GAMMARETROVIRUS ASSOCIATED WITH CANCER
Latest bibliographic data on file with the International Bureau
Pub. No.: WO/2006/110589 International Application No.: PCT/US2006/013167
Publication Date: 19.10.2006 International Filing Date: 07.04.2006
IPC: C12N 7/00 (2006.01), A61K 39/21 (2006.01), C07K 14/15 (2006.01), C12N 15/11 (2006.01), C12N 15/63 (2006.01), C12N 5/10 (2006.01), C12N 7/02 (2006.01), C12Q 1/68 (2006.01), G01N 33/50 (2006.01), G01N 33/569 (2006.01)
Applicants: THE CLEVELAND CLINIC FOUNDATION [US/US]; CCF INNOVATIONS/D20, 9500 Euclid Avenue, Cleveland, Ohio 44195 (US) (All Except US).
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 111 Franklin Street, 12th Floor, Oakland, California 94607 (US) (All Except US).
SILVERMAN, Robert [US/US]; (US) (US Only).
KLEIN, Eric, A. [US/US]; (US) (US Only).
DERISI, Joseph [US/US]; (US) (US Only).
GANEM, Don [US/US]; (US) (US Only).
CASEY, Graham [US/US]; (US) (US Only).
Inventors: SILVERMAN, Robert; (US).
KLEIN, Eric, A.; (US).
DERISI, Joseph; (US).
GANEM, Don; (US).
CASEY, Graham; (US).
Agent: COLLINS, Anne, J. et al.; HAMILTON, BROOK, SMITH & REYNOLDS, P.C., 530 Virginia Road, P.O. Box 9133, Concord, Massachusetts 01742-9133 (US) .
Priority Data:
60/669,473 07.04.2005 US
60/751,809 19.12.2005 US
Title: GAMMARETROVIRUS ASSOCIATED WITH CANCER
Abstract: The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
(WO/2006/110589) GAMMARETROVIRUS ASSOCIATED WITH CANCER
Latest bibliographic data on file with the International Bureau
Pub. No.: WO/2006/110589 International Application No.: PCT/US2006/013167
Publication Date: 19.10.2006 International Filing Date: 07.04.2006
IPC: C12N 7/00 (2006.01), A61K 39/21 (2006.01), C07K 14/15 (2006.01), C12N 15/11 (2006.01), C12N 15/63 (2006.01), C12N 5/10 (2006.01), C12N 7/02 (2006.01), C12Q 1/68 (2006.01), G01N 33/50 (2006.01), G01N 33/569 (2006.01)
Applicants: THE CLEVELAND CLINIC FOUNDATION [US/US]; CCF INNOVATIONS/D20, 9500 Euclid Avenue, Cleveland, Ohio 44195 (US) (All Except US).
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 111 Franklin Street, 12th Floor, Oakland, California 94607 (US) (All Except US).
SILVERMAN, Robert [US/US]; (US) (US Only).
KLEIN, Eric, A. [US/US]; (US) (US Only).
DERISI, Joseph [US/US]; (US) (US Only).
GANEM, Don [US/US]; (US) (US Only).
CASEY, Graham [US/US]; (US) (US Only).
Inventors: SILVERMAN, Robert; (US).
KLEIN, Eric, A.; (US).
DERISI, Joseph; (US).
GANEM, Don; (US).
CASEY, Graham; (US).
Agent: COLLINS, Anne, J. et al.; HAMILTON, BROOK, SMITH & REYNOLDS, P.C., 530 Virginia Road, P.O. Box 9133, Concord, Massachusetts 01742-9133 (US) .
Priority Data:
60/669,473 07.04.2005 US
60/751,809 19.12.2005 US
Title: GAMMARETROVIRUS ASSOCIATED WITH CANCER
Abstract: The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)