gregh286
Senior Member
- Messages
- 980
- Location
- Londonderry, Northern Ireland.
hi,
i just want to write somethings about metabolic factors that i notice that may help people in due course.
I believe my CFS is and was caused by inhibition of phosphofructokinase from excess alcohol, this is a key enzyme in the control of
glycolysis.
https://www.hindawi.com/journals/bri/2013/495135/
As I in mild category now, I can walk over 6 miles with little PEM, I get some lactic build up, but I can pass its quickly with sauna and baths.
Nonetheless, as I noticed last few weeks, even small amount of carb 10-15g will rise the HR by 50% during golf. 70 - 100/105 bpm.
Last 2 times I only ate cheese, HR never budged from 70-75 BPM, and I never felt any lactate build up at all. But by this time I had'nt ate
anything for 17 hours, so likely body has spent nearly all short term glucose.
Even I notice HR rising with nuts, avocado, etc, which are 10%+ carbs, so not all fats created equal. It seems body very sensitive to carb under
exercise. Less so in my case when sitting around.
I also believe high doses of lemons and apple cider vinegar are stimulating this phoso enzyme, also there are some members who seen this benefit, even grapefruit which this citrus acid also helping stimulate the kreb cycle.
Also, as day progresses, body has more ability to burn carbs, morning is out, evening is more tolerable. I think that why we improve marginally during day.
Just one individuals experience with this crazy carry on.
The pfk1 enzyme also gets inhibited by aerobic activity driving a vicious cycle and go some way to explain how exceptional athletes also get ME.
PFK1 is also inhibited by low pH levels which augment the inhibitory effect of ATP. The pH falls when muscle is functioning anaerobically and producing excessive quantities of lactic acid(although lactic acid is not itself the cause of the decrease in pH[11]). This inhibitory effect serves to protect the muscle from damage that would result from the accumulation of too much acid.[2]
https://en.m.wikipedia.org/wiki/Phosphofructokinase_1#cite_note-11
Notice also how serotonin activates pfk1 also....
i just want to write somethings about metabolic factors that i notice that may help people in due course.
I believe my CFS is and was caused by inhibition of phosphofructokinase from excess alcohol, this is a key enzyme in the control of
glycolysis.
https://www.hindawi.com/journals/bri/2013/495135/
As I in mild category now, I can walk over 6 miles with little PEM, I get some lactic build up, but I can pass its quickly with sauna and baths.
Nonetheless, as I noticed last few weeks, even small amount of carb 10-15g will rise the HR by 50% during golf. 70 - 100/105 bpm.
Last 2 times I only ate cheese, HR never budged from 70-75 BPM, and I never felt any lactate build up at all. But by this time I had'nt ate
anything for 17 hours, so likely body has spent nearly all short term glucose.
Even I notice HR rising with nuts, avocado, etc, which are 10%+ carbs, so not all fats created equal. It seems body very sensitive to carb under
exercise. Less so in my case when sitting around.
I also believe high doses of lemons and apple cider vinegar are stimulating this phoso enzyme, also there are some members who seen this benefit, even grapefruit which this citrus acid also helping stimulate the kreb cycle.
Also, as day progresses, body has more ability to burn carbs, morning is out, evening is more tolerable. I think that why we improve marginally during day.
Just one individuals experience with this crazy carry on.
The pfk1 enzyme also gets inhibited by aerobic activity driving a vicious cycle and go some way to explain how exceptional athletes also get ME.
PFK1 is also inhibited by low pH levels which augment the inhibitory effect of ATP. The pH falls when muscle is functioning anaerobically and producing excessive quantities of lactic acid(although lactic acid is not itself the cause of the decrease in pH[11]). This inhibitory effect serves to protect the muscle from damage that would result from the accumulation of too much acid.[2]
https://en.m.wikipedia.org/wiki/Phosphofructokinase_1#cite_note-11
Notice also how serotonin activates pfk1 also....
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