lansbergen
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Neuroscience Letters 388 (2005) 21–26
Impaired exercise capacity, but unaltered mitochondrial respiration in
skeletal or cardiac muscle of mice lacking cellular prion protein
abstract http://www.ncbi.nlm.nih.gov/pubmed/16039050
Impaired exercise capacity, but unaltered mitochondrial respiration in
skeletal or cardiac muscle of mice lacking cellular prion protein
.For this purpose, we submitted Prnp0/0 animals to different protocols of exercise, and compared their performance to that of their respective wild-type controls. Prnp0/0 mice showed an exercise-dependent impairment of locomotor activity
Taken together, these results suggest that Prnp0/0 mice presented impaired swimming capacity when compared with wild controls. This effect was dependent on the weight they carried tied to their tail, thus suggesting that the muscular activity of these animals was impaired in a load-dependent manner.
abstract http://www.ncbi.nlm.nih.gov/pubmed/16039050
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