Estrogen Status in CFS

[Swim15]

I know there are sex differences in CFS - unlucky male here - but Is anyone familiar with how estrogen status possibly impacts the course of CFS?

I ask mainly because I was previously a bodybuilding competitor and used PEDs for years and was very comfortable with knowing my body’s estrogen metabolism, tolerance for it, how much anti estrogens to use, etc.

Now, however, after CFS I have a very VERY high tolerance to estrogen and nothing gives me high e2 symptoms like sensitive/puffy nipples, moodiness, bloating, etc.

Just as an example, I got slight gyno at one point that’s gone away with time from a low dose (20mg) course of dianabol. Now I can take 50-75mg+ a day with no estrogen symptoms and it does make me feel a little bit better.

Anyone know if there’s any downside to increasing estrogen status in CFS patients?

 

[heapsreal]

I know there are sex differences in CFS - unlucky male here - but Is anyone familiar with how estrogen status possibly impacts the course of CFS?

I ask mainly because I was previously a bodybuilding competitor and used PEDs for years and was very comfortable with knowing my body’s estrogen metabolism, tolerance for it, how much anti estrogens to use, etc.

Now, however, after CFS I have a very VERY high tolerance to estrogen and nothing gives me high e2 symptoms like sensitive/puffy nipples, moodiness, bloating, etc.

Just as an example, I got slight gyno at one point that’s gone away with time from a low dose (20mg) course of dianabol. Now I can take 50-75mg+ a day with no estrogen symptoms and it does make me feel a little bit better.

Anyone know if there’s any downside to increasing estrogen status in CFS patients?

Theres a couple of good utube sources, the lifting dermatologist, although gets repetitive theres good info backed up by studies. Basically they say leave estrogen alone unless getting gyno as the estrogen in men in cardio and neuro protective. They are very much against ai use. And generally encourage running testosterone if you are planning to run an anabolic with it such as deca etc purely for the estrogen conversion. The actual anabolics most dont aromatize very much.

 

[Swim15]

Theres a couple of good utube sources, the lifting dermatologist, although gets repetitive theres good info backed up by studies. Basically they say leave estrogen alone unless getting gyno as the estrogen in men in cardio and neuro protective. They are very much against ai use. And generally encourage running testosterone if you are planning to run an anabolic with it such as deca etc purely for the estrogen conversion. The actual anabolics most dont aromatize very much.

Yeah I know all this - I’ve been coaching national level bodybuilders on the side for years.

Curious about the impact of estrogen status on CFS though if anyone is familiar with the topic

 

[heapsreal]

Yeah I know all this - I’ve been coaching national level bodybuilders on the side for years.

Curious about the impact of estrogen status on CFS though if anyone is familiar with the topic

Are you referring to guys using estrogen or controlling estrogen with a certain range. My time on this forum i have seen very little about it.
Personally i havent noticed anything specific to my estrogen levels and cfs that general population wouldnt have noticed ie severe muscle pain and cramps and generally shitty if e2 has crashed but thats not unusual for anyone

Probably seen abit more about guys using progesterone to help sleep or anxiety issues. I think a few guy's with pots/oi issues have had improvements with clen.

 

[Swim15]

Talking broadly about whether or not estrogen replacement (or whether 'high' or 'low' e2) has an impact on CFS.

I feel generally slightly better when I'm keeping e2 high but not sure if there are potential downsides to that. Also just somewhat curious as to why I'm very estrogen insensitive now (or, alternatively, converting much less) with CFS as opposed to before.

Seems like now there no limit to how much estrogen my body can handle without side effects

 

[Learner1]

Anyone know if there’s any downside to increasing estrogen status in CFS patients?

Yes, female cancers. (Spoken as a formerly estrogen dominant stage 3 uterine cancer survivor...)

Seems like now there no limit to how much estrogen my body can handle without side effects

A Dutch test would be useful and looking at all your hormones, and looking at if there are cancer drivers or not. Estrogen dominance is not good, and progesterone is one tool that can be used, but there are many others.

Pregnenolone has been shown to help me / CFS patients cognitive function, although in me, it all wants to go to estrone, not good. I find that taking a tiny bit of pregnenolone, and DHEA, testosterone, and progesterone is helpful, and now that I have no ovaries to produce any estrogen, my doctor has me taking mostly estriol and a tiny bit of estradiol.

Ensuring that one has good balanced hormone function, including thyroid and adrenal hormones, as a foundation for improving ones and ME/CFS.

 

[Swim15]

Luckily I’m not female in that regard so no risk for female cancers for me.

Do you know if stopping hormone replacement in females is recommended in CFS?