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Early immune stimulation & risk of neurological disorders

N

natasa778

Senior Member
Messages
1,774
http://nblo.gs/139I2d

Reporting results of a study where "early immune stimulation induced by postnatal systemic administration of LPS [lipopolysaccharide]" was performed in rats, researchers examined various potential effects on "the levels of monoamines (dopamine, serotonin) and their metabolites, and the levels of the main excitatory and inhibitory neurotransmitters glutamate and γ-aminobutyric acid (GABA) in the brain" and "activation of the kynurenine pathway of tryptophan metabolism." Brain morphology, and in particular, hippocampal volume was also the topic of some investigation...

... And with all that, again bearing in mind that this was a study of rats, the authors conclude that: "Our results suggest a pathogenetic link between early immune stimulation and neuropsychiatric disorders such and schizophrenia, mood disorders, anxiety disorders, autism, Parkinson’s disease and Alzheimer’s disease."
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Christopher

Christopher

Senior Member
Messages
576
Location
Pennsylvania
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