Does Parkinson's starts in the gut August 22, 2023

[keepontruckin]

https://www.sciencedaily.com/releases/2023/08/230822151748.htm

Who knows? Maybe me cfs could have a similar process happening too.

 

[almost]

Thank you for this @keepontruckin .

This is exacty what scares me about my particular case. Some of my symptoms, some of my NutrEval results, are those that can be found in Parkinson's, MS, MLS, etc., just not fully developed yet; or not. My neurologists all say, no, of course you don't have those things, but they only say you do when it's actually past the doorstep and now in your house, so to speak. If there are better ways to detect early and rule something in or out, that would be welcome.

 

[hapl808]

The more I learned about the microbiome and such, the more I believe we'll eventually find that not only neurological disorders are gut related, but also mental illness may be related to gut disruption at some point in life. I also think it is a two-way communication, whether it's vagal or some other process - the brain regulates the gut, the gut regulates the brain. So maybe it's chicken and the egg.

 

[lenora]

I'm 76 and have had gut problems since I was, well, since I can remember. As we age, the light comes on: We're going to die of something. Believe it or not, one actually gets used to the idea. I was once young (yesterday) and now I'm old (today) and will be even older in the future. I'm only heading one way.

I'm sure we would all like to die of a blood clot in our sleep. No one wants to suffer and we are, after all, human. I've given up what I WANT and have accepted whatever it is that comes along. I just don't want a lot of pain or serious complications. Meanwhile, I'm trying to live my life and enjoy it as much as possible.

 

[datadragon]

The more I learned about the microbiome and such, the more I believe we'll eventually find that not only neurological disorders are gut related, but also mental illness may be related to gut disruption at some point in life. I also think it is a two-way communication, whether it's vagal or some other process - the brain regulates the gut, the gut regulates the brain. So maybe it's chicken and the egg.

The Gut-Brain axis is being studied ongoing. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703666/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709456/ are just two I pulled. 'Gut Disruption' can be caused from inflammation and infection, or even from a nutrient deficiency, explaining why there is such a wide variety of contributors since there are so many factors that can induce inflammation (NLRP3 activation) or zinc deficiency.

 

[Violeta]

Probably starts in the cell.

Parkinson's is very well studied and CFS/ME is not. Studies about Parkinson's is a good place to look for your own research into remedies for CFS/ME.

Examples:


Thiamine deficiency (TD) is associated with an increased risk of PD. In PD patients, there is a decrease in the level of α-ketoglutarate dehydrogenase complex (an enzyme associated with TD) in the SNpc region of the brain. This reduction is correlated with degeneration severity [26]



"Several studies have shown significant global reductions in the level of pantothenic acid in the brains of multiple forms of neurodegeneration, including Huntington's disease, Parkinson's disease, and AD, which may be causative of the mitochondrial dysfunction (Patassini et al., 2019; Xu et al., 2020)."



https://pubmed.ncbi.nlm.nih.gov/31834548/

Neuroprotective effects of Bacopa monnieri in Parkinson's disease model​