Hutan
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http://www.skynews.com.au/news/national/qld/2016/06/21/crucial-step-made-in-migraine-research.html
Tuesday, 21 June 2016
Tuesday, 21 June 2016
The world's largest study of migraines co-led by an Australian researcher, published in Nature Genetics, has discovered dozens of new genes linked to their onset.
...
Queensland University of Technology's Associate Professor Dale Nyholt, who co-led the study that involved 60,000 patients, says they have taken a crucial step to uncovering the biological causes of migraine through the use of genetics.
Researchers have identified 44 independent DNA variants robustly associated with migraine risk that mapped to 38 distinct genes, including 28 not previously reported.
What the findings indicate is that vascular dysfunction is a primary underlying cause of migraine, not brain dysfunction.
'Although it remains likely that neurogenic mechanisms are also involved in migraine, the vascular finding is consistent with known comorbidities and previously reported shared genetic risk among migraine, stroke, and cardiovascular diseases,' Dr Nyholt said.
...
Dr Nyholt says the hope is that the new research will lead to the re-purposing of existing drugs that can target vascular dysfunction to treat migraine.
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