heapsreal
iherb 10% discount code OPA989,
- Messages
- 10,223
- Location
- australia (brisbane)
Hi Rich, have your views changed much from this in 2009, would d-ribose fit into this as well??
http://www.me-cfsmethylation.com/viewtopic.php?f=3&t=182
Hi all.
In the past, a few PWCs have mentioned supplementing creatine, and some have reported benefits from doing that.
In the past, I had thought that supplemental creatine might provide benefit in terms of supplying more storage capacity for energetic phosphate, which the cells (particularly muscle cells) can use to regenerate ATP during times of high demand, such as a burst of physical activity. I didn't see any advantage over the longer term, though, because the ATP production rate would continue to be limited by the mitochondrial dysfunction, which I attribute fundamentally to glutathione depletion in CFS.
Well, now I've come to see some of this in a different light, in view of comments from Dr. Lee Cowden in his chapter of the new book by Connie Strasheim, Insights into Lyme Disease Treatment.
Dr. Cowden pointed out that since such a large fraction of the body's methylation is used to produce creatine, by supplementing creatine, some of the load can be taken off the methylation cycle so that more of the methylation can be used for other reactions. (Note that there are at least 50 known methylation reactions in the body, and it is thought that there are probably many more that have not yet been specifically identified.)
This could give temporary help to the methylation reactions until the methylation cycle can be brought up to normal.
Note that the other major user of methylation in the body (and perhaps the main one) is the formation of phosphatidylcholine from phosphatidylethanolamine, so supplying phos. choline as a supplement might help in this same way in terms of freeing up methylation capacity for other uses. Note also that there is some phos. choline in the phosphatidlyserine complex that is part of the protocol.
I don't know what dosages would be appropriate. As you may know, some bodybuilders and athletes take large quantities of creatine, in the range of several grams per day.
It's important that the kidney function be normal when taking creatine, in order that the resulting creatinine will be excreted in the urine.
Anecdotal reports of adverse effects to the FDA from taking creatine have included rash, shortness of breath, vomiting, diarrhea, nervousness, anxiety, migraine, fatigue, polymyositis, myopathy, seizures and atrial fibrillation. I don't know what dosages caused these adverse effects.
I would be interested to hear from PWCs who have tried taking creatine, as to what sorts of improvements they have noted from taking it, if any.
Thanks,
Rich
http://www.me-cfsmethylation.com/viewtopic.php?f=3&t=182
Hi all.
In the past, a few PWCs have mentioned supplementing creatine, and some have reported benefits from doing that.
In the past, I had thought that supplemental creatine might provide benefit in terms of supplying more storage capacity for energetic phosphate, which the cells (particularly muscle cells) can use to regenerate ATP during times of high demand, such as a burst of physical activity. I didn't see any advantage over the longer term, though, because the ATP production rate would continue to be limited by the mitochondrial dysfunction, which I attribute fundamentally to glutathione depletion in CFS.
Well, now I've come to see some of this in a different light, in view of comments from Dr. Lee Cowden in his chapter of the new book by Connie Strasheim, Insights into Lyme Disease Treatment.
Dr. Cowden pointed out that since such a large fraction of the body's methylation is used to produce creatine, by supplementing creatine, some of the load can be taken off the methylation cycle so that more of the methylation can be used for other reactions. (Note that there are at least 50 known methylation reactions in the body, and it is thought that there are probably many more that have not yet been specifically identified.)
This could give temporary help to the methylation reactions until the methylation cycle can be brought up to normal.
Note that the other major user of methylation in the body (and perhaps the main one) is the formation of phosphatidylcholine from phosphatidylethanolamine, so supplying phos. choline as a supplement might help in this same way in terms of freeing up methylation capacity for other uses. Note also that there is some phos. choline in the phosphatidlyserine complex that is part of the protocol.
I don't know what dosages would be appropriate. As you may know, some bodybuilders and athletes take large quantities of creatine, in the range of several grams per day.
It's important that the kidney function be normal when taking creatine, in order that the resulting creatinine will be excreted in the urine.
Anecdotal reports of adverse effects to the FDA from taking creatine have included rash, shortness of breath, vomiting, diarrhea, nervousness, anxiety, migraine, fatigue, polymyositis, myopathy, seizures and atrial fibrillation. I don't know what dosages caused these adverse effects.
I would be interested to hear from PWCs who have tried taking creatine, as to what sorts of improvements they have noted from taking it, if any.
Thanks,
Rich
They also sell a lot amino acids.