Wow read this from
http://chronicfatigue.about.com/b/2010/01/07/british-xmrv-study-results-released.htm
ifthly, in the search of a diagnosis for CFS/ME, I stumbled upon a disease called Wilsons disease. A widely respected neurologist thought I might have Wilsons disease, because my ceruloplasmin and ceruloplasmin-bound copper levels in the blood were rather low : reduced ceruloplasmin levels and raised non-ceruloplasmin-bound copper levels. After quite some time, it turned out that I did not have Wilsons disease, because I had it all checked out with a genetician.
Nevertheless, I seemed to have quite a deal of things in common with people who have Wilsons disease. One of these things is that I seem to have Coombs-negative intravascular hemolysis or Coombs-negative immune hemolytic anemia, or Coombs test-negative hemolytic anemia, or Severe hemolytic anemia with a negative Coombs test. Acute hemolytic anemia is found in Wilsons disease : Coombs-Negative Hemolytic Anemia is a recognized but rare (10-15%) complication of Wilson Disease. But also in human T-lymphotrophic virus 1 (HTLV-1) retrovirus, you will find Coombs-negative hemolytic anemia. So, Coombs-negative acute or chronic hemolytic anemia seems to be retrovirus-mediated. High urine copper levels were first thought to be unique to Wilsons disease, but it is also found in cancer, and now there is a growing body of evidence that this problem also seems to be present in CFS/ME.
In MuLV retroviruses the amount of vascular endothelial growth factor (VEGF) is known to be increased, and as CFS/ME will turn out to be a MuLV-related disease, I can now truely say that there seems to be a high-level of constant compensation going on in CFS/ME for the shortage of red blood cells, so that regular blood tests in CFS/ME will never show a shortage of red blood cells : during the initial stages of CFS/ME even quite to the contrary. Why should that be the case ? In CFS/ME hemolytic anemia is a hidden problem, that you have to discover by a lot of good thinking ! The amount of vascular endothelial growth factor (VEGF) is increased in CFS/ME. VEGF is undoubtedly increased in CFS/ME in order to constantly save the patients life. VEGF stimulates the generation of red blood cells : VEGF stimulates erythropoiesis. A CFS/ME individual is constantly fighting for his life.
But increased VEGF or upregulation of VEGF is also known to be associated with neurodegeneration in MuLV. So there is constant fighting against neurodegeneration going on, and that is most probably part of all the exhaustion being experienced in CFS/ME.
So a lot of red blood cells are constantly being destroyed in CFS/ME, resulting in copper being released from the red blood cells into the urine which is frequently shown in high urine copper levels, not at a same beautiful constant level as in Wilsons disease, but more in a waxing and waning way, which is why people with CFS/ME are chronically extremely fatigued and exhausted in the same waxing and waning way.
And in CFS/ME there is not only this problem with red blood cells, but there is also this problem with neutrophils (a type of white blood cells), because these neutrophils are being recruited especially to areas of infection and inflammation in the brain and the spinal cord, and also to areas of infection and inflammation in the Gastrointestinal (GI) Tract, such as stomach and intestines.
In order to compensate for all this retrovirus-induced loss of red blood cells and white blood cells (neutrophils), there is a chronic necessity for the production of new red blood cells and new white blood cells (especially neutrophils). All of these cells have to be newly produced at a much quicker rate than normally should have been the case in normal everyday human individuals, who are not infected with this Xenotropic MuLV-related retrovirus (XMRV), and who do not have such a debilitating disease such as is the case with CFS/ME. The result of all this, is that people with CFS/ME are chronically dehydrated, because there are often times when there is too much presence at the same time of not only the old destroyed blood cells, but also the newly produced blood cells, making the CFS/ME bodily environment overcrowded with blood cells, new ones and old ones all at the same time, resulting in a chronic dehydration, which is a hellish experience, you never get quite used to.
