I've been seeing the pubmed stuff on that drug. I tend to give constipation drugs plenty of time in the market before considering them. They have a fairly nasty track-record with being pulled. Hope this one is different.
Wise move.
Doesn't look to be any different in real life situations though. Preliminary results I'm seeing so far in another forum is that the response is similar to the other meds, works for some, doesn't work for others but is most effective when other laxative measures are still taken along with it.
I don't know if it's just me but I found another cure for constipation. I noticed shortly after starting a nitrate that I was prescribed for intestinal ischemia that my problem with constipation changed to become one of diarrhea. I couldn't get a plausible explanation from any doctor as to how or why it would occur but I was reading just the other day that boosting nitric oxide can cause diarrhea as it also has a secretagogue mechanism in opening chloride channels,same as these newer constipation meds.
I have always just used Epsom Salts as a laxative and have to continue with that too otherwise my bowels become too sluggish so maybe that's the combination required for efficacy.
http://scialert.net/fulltext/?doi=ijp.2011.31.39
[NO is involved in the intestinal water transport by acting directly on the epithelium and blood flow or indirectly by stimulating neuronal reflexes and releases of, or interactions, with other agents. For example, NO activates soluble guanylate cyclase and this result in cGMP generation, a potent activator of intestinal secretion (
Brasitus et al., 1976). Nitric oxide donors, such as sodium nitroprusside, S-nitroso- N-acetylpenicillamine and isosorbide dinitrate, stimulated mucus secretion from a suspension of isolated gastric cells.
NO can also induce vasoactive intestinal polypeptide-an important neurotransmitter, in secretomotor neurons (
Allescher et al., 1996). Furthermore, NO causes an increase of prostaglandin E2 production, a known secretory molecule (
Wilson et al., 1996). Apart from indirect effects on secretory molecules, NO may also exert direct secretory effects by opening of chloride channels (
Tamai and Gaginella, 1993). It is one of the mediators of the intestinal secretion and laxative-induced diarrhea induced by castor oil (
Mascolo et al., 1993), magnesium sulfate (
Izzo et al., 1994) and anthraquinone containing laxatives such as senna and cascara.]
