pattismith
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An Overview of Circular RNAs and Their Implications in Myotonic Dystrophy
Karol Czubak 1, Saam Sedehizadeh 2, Piotr Kozlowski 1,* and MarzenaWojciechowska 1,*
…"The expression of circRNAs has recently been reported to generally decrease in human cancers [33–35] and increase in some late-onset human neurological and muscular disorders [9,15,36–40] suggesting that their expression can be drastically altered and potentially contribute to pathological states.
There are reports suggesting circRNA involvement in cardiovascular and autoimmune conditions [41–46].
CircRNA functions may also be related to their elevated stability that is higher than their linear counterpart mRNAs, which may reflect the fact that these small molecules have been found to accumulate with age especially in tissues of low proliferative capacity.
Notably, circRNA abundance tends to increase during the differentiation process, and they were found to be highly expressed in mammalian brain and striated muscle tissues (both skeletal and cardiac) and they are one of the body tissues showing the highest levels of alternative splicing.
Lately, an elevated pattern of expression of circRNAs was documented in skeletal muscles of patients suffering from Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) [36,40,47,48]. In both the diseases the differential expression of circRNAs levels was correlated with aberrant alternative splicing."...
Karol Czubak 1, Saam Sedehizadeh 2, Piotr Kozlowski 1,* and MarzenaWojciechowska 1,*
…"The expression of circRNAs has recently been reported to generally decrease in human cancers [33–35] and increase in some late-onset human neurological and muscular disorders [9,15,36–40] suggesting that their expression can be drastically altered and potentially contribute to pathological states.
There are reports suggesting circRNA involvement in cardiovascular and autoimmune conditions [41–46].
CircRNA functions may also be related to their elevated stability that is higher than their linear counterpart mRNAs, which may reflect the fact that these small molecules have been found to accumulate with age especially in tissues of low proliferative capacity.
Notably, circRNA abundance tends to increase during the differentiation process, and they were found to be highly expressed in mammalian brain and striated muscle tissues (both skeletal and cardiac) and they are one of the body tissues showing the highest levels of alternative splicing.
Lately, an elevated pattern of expression of circRNAs was documented in skeletal muscles of patients suffering from Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) [36,40,47,48]. In both the diseases the differential expression of circRNAs levels was correlated with aberrant alternative splicing."...