CFS / CIRS recommended diagnostic plan?

C

concerned_husband

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9
Location
Seattle WA
For getting tested for Chronic Inflammatory Response Syndrome (CIRS), Dr. Shoemaker recommends:
  1. neuropeptide regulation of inflammation (MSH, VIP)
  2. inflammatory processes out of control (TGF beta-1, C4a, MMP-9)
  3. gene susceptibility (HLA DR)
  4. hormonal dysregulation (ADH/osmolality, ACTH/cortisol, androgens)
  5. hypoxia inducible factor regulated compounds (VEGF, erythropoietin, TGF beta-1)
  6. autoimmunity (TGF beta-1, AGA, ACLA, ANA, ANCA, actin)
  7. cellular basis of immune regulation (TH17 immunity, TGF beta-1)

I know there isn’t any one of these tests that will definitely confirm anything; rather it’s having multiple tests and having them all point towards a positive diagnosis for CIRS.

Does anyone have a recommendation for the order of getting these tests done? Or have people opted to get most (or all) of these labs at once after they suspect being sick with CIRS? We are hoping with after HLA, MSH, Leptin, C4a, TGF-b1 we will have enough data to work with her doctor on a positive (hopefully) diagnosis (so we can start treatment!!).

Tests my wife has had:
  1. HLA (DRB1: 01, DRB1: 14; DRB3: 52B; DQ: 05)
  2. MSH (11)
  3. Leptin (6.4)

Test we were planning on getting next (based on Dr. Shoemaker’s writings that C4a:
  1. C4a
  2. TGF-b1
  3. The rest (VIP, MMP-9, VEGF, and a bunch of other long acronym ones) we were planning on waiting on given that they’re (I believe) more difficult to get tested because they require dry ice shipment and probably other factors as well.
 
Seven7

Seven7

Seven
Messages
3,446
Location
USA
wait is this a new name??? or different disease Chronic Inflammatory Response Syndrome (CIRS)??
 
C

concerned_husband

Messages
9
Location
Seattle WA
Yes, that's correct. CIRS is essentially a large umbrella that other inflammatory illnesses can be categorized under (Fibyro, Chronic fatigue, Lyme's, and others).

This grouping was done by Shoemaker based on the commonality of symptoms and that some test results that are similar (while some are obviously going to be different as the actual different illnesses can manifest in each test differently depending on the condition).
 
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