【CFS＋ADHD】Is there a form of ADHD for which increased dopamine can be counterproductive?

[cfsJapan]

I suffer from ADHD and CFS, and have tried various medications, but methylphenidate has no effect at all. (Rather, it worsens my hyperactivity and stereotyped behavior, and reduces my work ability.)

So I tried Atomoxetine, but it only caused side effects and had no effect.

However, my ADHD improves significantly when I take drugs that increase noradrenaline, so I tried Nortriptyline (tricyclic antidepressants), and my task processing ability improved significantly. However, it significantly extends my QT, so I cannot use it for long.

Also, I have a strange constitution and react sensitively (or badly) to many drugs that involve cyp2d6, but Cymbalta did not cause any side effects at all.

(However, Cymbalta became completely ineffective after the first two months.)

In this case, are there any recommended drugs to improve my ADHD?

I would be happy if you could suggest something, even if it is an unconventional method or a drug that is beyond my imagination.

My life is a mess because of ADHD (and technically CFS).

*Medications I've tried in the past

Methylphenidate, Abilify, bupropion → I had the same bad reaction

Nortriptyline, Imipramine → Improved ADHD

Cymbalta, milnacipran, Desvenlafaxine → Only helped for the first few months

Also, I feel like antipsychotics like Blonanserin might help my ADHD, but am I overthinking it?

Clonazepam and Lamotrigine help my ADHD
a little,

which is strange because dopamine makes my ADHD much worse anyway.

 

[linusbert]

konnichiwa,

you can true to reinforce those neurotransmitters with food and vitamins.
foods like banana have tryptophan and vitamin b6. egg yolks do have cholin which is also important here.
than vitamin b6 is strongly involved with neurotransmitters, but in second hand all vitamins are so it should be a b complex.

look into methylation, which is basically the pathway to neurotransmitters. usually methylation is boosted with methylfolate, methylcobalamin, b6, b2 and b1 (but all b vitamins should be taken).
we have methylation protocols in this forum as a starter.

but using chatgpt or grok or any other competent AI can walk you through the process and give better explanation.

beware though, some vitamins like b6 can have paradoxical symptoms, like making it worse. or making it worse and then better. or making one symptome better and introducing new others.
its important to have cofactors like potassium and magnesium and phosphor etc in mind, especially as a electrolyte imbalance can also prolong the QT. actually prolonged QTc is a possible symptom of a potassium or magnesium deficiency.