While I can't comment on the protocol, one fundamental aspect mentioned describing the reason for using an enzyme is, frankly, incorrect - "breaking the cell wall" (
http://buhnerhealinglyme.com/the-protocols/). Mycoplasma lack a cell wall - that's what makes them mycoplasma and not bacteria. So, it makes me suspicious from the outset. The whole cell wall argument though, IS key for lyme-causing bacteria as I recall, so perhaps it is an editorial mistake. But, be that as it may...
I was on a protocol suggested by Dr Nicolson (can't find the paper, it was circa 2006). My functional medicine doctor (trained in immunology), after confirmed by testing, prescribed a rotating regimen of 2 weeks Doxycycline, then 2 weeks Cipro, and 2 weeks clarithromycin. Later on, a 2 week 'off' period was added at the end of the cycle. I was on it for about a year and a half and stopped (on the doctor's recommendation/advise) when I couldn't keep my intestinal flora up any more. My doctor explained that mycoplasma are often intracellular (glom onto the outside of cells and make them go wonky is the non-tech version), so eliminating is very slow and tedious. And yes, there was/is a significant diet/supplement end to it.
After getting over the very significant herx (for me didn't come on right away and was out when I went from 60% to 20%) I think my functioning improved. In my case, I don't think mycoplasma were the whole cause. I was tested before treatment (a specialized test - PCR, cost $450, by our public health unit, which confirmed them present) but couldn't afford testing after to see if it was gone.
Subsequently, my health has deteriorated (too tired to go back and check timing/sequence). Before long-term antibiotics (natural or pharma) read the warning in the recent q/a from OMF and Dr. Naviaux about antibiotics and antivirals.
Best of luck in the battle!
