pattismith
Senior Member
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Myopathy may be an alternative diagnose is ME/CFS patients....
Here it's about paraspinaux muscle atrophy, which comes with bad posture...
Axial myopathy: an overlooked feature of muscle diseases
2016
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The most well-known predominant axial myopathy is probably selenoprotein deficiency characterized by rigid spine, scoliosis and respiratory insufficiency, often while still ambulatory ( Jungbluth et al. , 2011 ).
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Another classic, mostly axial, myopathy is due to mutations in the lamin A/C gene characterized by cardiac arrhythmias, proximal weakness, contractures and axial muscle involvement ( Bonne et al. , 2000 ; Quijano-Roy et al. , 2012 ; Maggi et al. , 2014 ).
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Two metabolic myopathies: glycogen storage disease type II (GSDII, Pompe disease, acid maltase deficiency) and McArdle disease (glycogen storage disease type V) also may have pronounced paraspinal affection.
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Recently, a novel predominantly axial hereditary myopathy was coined with mutations in the ryanodine receptor 1 ( RYR1 ) gene. Aberrations in RYR1 are responsible for several other myopathies.
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A relatively common inflammatory myopathy is the isolated neck extensor myopathy (INEM) with onset after age 60 ( Katz et al. , 1996 ; Kastrup et al. , 2008 ; Muppidi et al. , 2010 ).
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Finally, radiation may, in ∼11% of exposed, induce a predominant axial myopathy with a latency of, on average, 15 years.
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Data collected so far suggest that axial muscles could possibly be considered the body’s most proximal musculature and hence the first to be involved in proximal myopathies.
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Healthy paraspinal musculature shows age-dependent fatty infiltration and atrophy of the paraspinal musculature spreading from the deep to the superficial musculature, whereas the opposite happens in patients with FSHD1. Temporal evolution of paraspinal myopathy may therefore have diagnostic implications.
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https://academic.oup.com/brain/article/139/1/13/2468815?login=false
Here it's about paraspinaux muscle atrophy, which comes with bad posture...
Axial myopathy: an overlooked feature of muscle diseases
2016
...
Myopathies with predominant axial involvement
Predominant axial myopathies usually have clinically evident paraspinal affection with rigid spine or abnormal posture.The most well-known predominant axial myopathy is probably selenoprotein deficiency characterized by rigid spine, scoliosis and respiratory insufficiency, often while still ambulatory ( Jungbluth et al. , 2011 ).
...
Another classic, mostly axial, myopathy is due to mutations in the lamin A/C gene characterized by cardiac arrhythmias, proximal weakness, contractures and axial muscle involvement ( Bonne et al. , 2000 ; Quijano-Roy et al. , 2012 ; Maggi et al. , 2014 ).
....
Two metabolic myopathies: glycogen storage disease type II (GSDII, Pompe disease, acid maltase deficiency) and McArdle disease (glycogen storage disease type V) also may have pronounced paraspinal affection.
....
Recently, a novel predominantly axial hereditary myopathy was coined with mutations in the ryanodine receptor 1 ( RYR1 ) gene. Aberrations in RYR1 are responsible for several other myopathies.
...
A relatively common inflammatory myopathy is the isolated neck extensor myopathy (INEM) with onset after age 60 ( Katz et al. , 1996 ; Kastrup et al. , 2008 ; Muppidi et al. , 2010 ).
...
Finally, radiation may, in ∼11% of exposed, induce a predominant axial myopathy with a latency of, on average, 15 years.
....
Myopathies with prominent paraspinal involvement as part of more widespread myopathy
..............................................................................Discussion
Axial myopathy has received little attention in clinical practice and research, but based on the studies reviewed in this paper, it appears to be a grossly underestimated feature of many muscle diseases. When evaluated by MRI, paraspinal musculature is typically among the most severely affected muscles ( Kesper et al. , 2009 ; Quijano-Roy et al. , 2012 ), but strikingly few MRI studies include paraspinal muscles in muscle imaging.Data collected so far suggest that axial muscles could possibly be considered the body’s most proximal musculature and hence the first to be involved in proximal myopathies.
.............
Healthy paraspinal musculature shows age-dependent fatty infiltration and atrophy of the paraspinal musculature spreading from the deep to the superficial musculature, whereas the opposite happens in patients with FSHD1. Temporal evolution of paraspinal myopathy may therefore have diagnostic implications.
.....
https://academic.oup.com/brain/article/139/1/13/2468815?login=false